Aarhus University Seal

Nykjær Group

Receptor Neurobiology

Research activities are focused towards the functional characterization of a group of type-1 receptors denoted the Vps10p-domain family, or so-called sortlins, that comprises sortilin, SorLA, and SorCS-1, -2, and -3. The receptors are enriched in neurons where they mediate trafficking and signaling of a vast number of ligands such as neurotrophic factors along with their cognate receptors, neurotransmitter receptors, APP, and progranulin. Among many activities, the receptors regulate neuronal cell fate, differentiation, innervation, synaptic plasticity, and learning and memory. Key goals of the Nykjaer lab is to understand their functions in the heathy brain, dissect out their mode of actions, investigate how genetic variation contributes to disease development - in particular of neuropsychiatric disorders and memory impairment -, and to evaluate their potential as drug targets.

Methodologies include transgenic mice and zebrafish, a broad repertoire of molecular, cellular and genetic and viral tools, transcriptomics and (phospho)proteomics, neuroembryology, mouse behavior, electrophysiology and advanced imaging including high-resolution microscopy. In vivo fiber photometry and mesoscale single unit recordings are currently being implemented.

Available projects 

The Nykjær group currently has projects available for Master students and postdocs within the following research areas. 

Functions of the sortilin receptor family in health and disease:

  • Molecular mechanisms underlying memory and psychiatric disorders

Please contact Group Leader Anders Nykjær directly, if interested.

News

Previous news from the research group

News

Jeppe Tranberg-Jensen is new bachelor student in Nykjær Group

- People

Jeppe Tranbjerg-Jensen is a new bachelor student in Anders Nykjær group from February 1st. During the next 6 months, he will study axon outgrowth in…

Anne Kathrine Sørensen is new Research year student at Nykjær Group

- AndersNykjær

Anne Kathrine Sørensen started as a research year student in Anders Nykjær’s group per 16 October 2017. For the next year, she will focus on the…

New publiction by team leader Arne Möller and colleagues

- Research news

The title of the paper is: Hidden Twins: SorCS Neuroreceptors Form Stable Dimers

Prof. Anders Nykjær receives DKK 250.000 from Foundation for Research in Neurology

- Awards

Anders Nykjær receives DKK 250.000 for the project "Functional characterization of the multiple sclerosis risk gene SORCS3: a novel drug target".

Anders Nykjær interviewed for DR Science

- Knowledge exchange

On Neuroscience Day 2017, Group Leader Anders Nykjær was interviewed for two articles by DR Science.

DANDRITE researchers receive DFF-Research Project Grants from the Danish Council for Independent Research

- Awards

Core group leaders Anders Nykjær and Poul Nissen, group leader Sadegh Nabavi and team leader Magnus Kjærgaard are all recipients of research grants…

Two grants awarded to Anders Nykjaer

- Research news

Anders Nykjaer was granted DKK 750.000 by the Novo Nordisk Foundation for the project entitled “SorCS1 – boosting energy expenditure in obesity”. He…

New publication from Anders Nykjær's group - SorCS2 is required for BDNF-dependent plasticity in the hippocampus

- Research news

SorCS2 is a member of the Vps10p-domain receptor gene family receptors with critical roles in the control of neuronal viability and function. Several…