Aarhus University Seal

Vanwalleghem Team

Area of expertise: Gut-brain axis in larval zebrafish

We are what we eat, or so the saying goes. The enteric nervous system is a complex network that drives and regulates multiple gut functions such as motility, homeostasis, and nutrient uptake. The gut microbiome is also known to have bidirectional interactions with the enteric and central nervous system, forming the so-called gut-brain axis. Dysregulation of the microbiome has been correlated with several conditions such as autism spectrum disorder, depression or anxiety.

Our overarching goal is to understand how dysregulation of the bidirectional communication between the gut microbiome and the nervous system can affect behaviour and lead to mental health disorders. We use a transparent fish to look at the activity of neurons, using a fluorescent calcium indicator, in vivo and in real time. We plan to manipulate the microbiome of the animal to study how the enteric nervous system’s activity changes, and how that can affect behaviour. Furthermore, we plan to look at the interplay of neurons and immune cells in regulating the microbiome.

Gilles Claude Vanwalleghem is Team Leader at DANDRITE and assistant professor at the Department of Molecular Biology and Genetics (MBG). The lab is situated in the University City at Universitetsbyen 83, 8000 Aarhus C.

News

The Nordic EMBL Partnership launches an innovative collaborative postdoc programme

- Collaboration

Seven postdoctoral positions centered on collaboration, innovation, and interdisciplinary mentorship, are currently open for applications. The primary…

9.7 million DKK is awarded to 4 DANDRITE talents

- Grants and awards

Out of 20 grants, four DANDRITE postdocs have been awarded a Postdoc Grant from the Lundbeck Foundation, providing funding to delve deeper into the…

New Postdoc in Vanwalleghem Team

- People news

Marina Mantel is new Postdoc in Gilles Claude Vanwalleghem’s Team. Over the next 3 years, she will be working on untangling the links between the…