We are trying to understand the intracellular sorting pathways of VPS10p receptors, and how trafficking defects may underlie Alzheimer's disease (AD).
We are studying the role of sorLA as a neuronal sorting receptor for the Amyloid precursor protein, aiming to determine the mechanisms how sorLA activity protects against AD using biochemistry, cell biology, and animal model systems. Current research focus to understand the regulation of sorLA gene expression, including the correlation between SNPs in the SORL1 gene (encoding sorLA protein) and AD, as well as to understand the physiological function of sorLA in the developing retina.
There are currently projects available for Master and PhD students. Please contact Olav Andersen directly for more information, if interested.