Research focus:

How do chromatin regulators shape neuronal identity during brain development, and how does their dysfunction contribute to neurodevelopmental disorders like autism and schizophrenia? How do neuronal chromatin states dynamically respond to environmental stimuli, and could such responses encode a form of chromatin memory? What epigenetic mechanisms govern interactions between neurons and other brain cell types, such as microglia?

These are some of the fundamental questions driving our research. Our lab investigates chromatin regulatory processes and gene expression programs that orchestrate human neurodevelopment and are disrupted in brain disorders. We aim to transform our understanding of how chromatin regulation underlies neuronal identity, cell-cell communication, and stimulus response across developmental timelines. To achieve this, we use a combination of cutting-edge approaches, including functional genomics, multi-omics integration, CRISPR-based perturbations, and single-cell sequencing in human brain cell models.