Bachelor project – example of a recent bachelor project is Immunohistochemical analysis of pathologic alpha-synuclein in brains from mouse model of Parkinson’s disease and other projects can be established based on the larger on-going research projects in the group.
Master project – example of a recent master project is Early Pathogenic gene expression response in neuron during intracellular alpha-synuclein aggregation and other projects can be established based on the larger on-going research projects in the group.
PhD project and postdoctoral projects – candidates with an interest in applying for fellowships with our groups area of expertise are welcome to contact us for further discussion.
Lab background:
Our group has long record in studying alpha-synuclein and its relation to Parkinson’s disease and dementia. Currently we are focusing on the mechanisms whereby intracellular alpha-synuclein aggregates contributes to progressive neurodegeneration and disease modifying strategies targeting these mechanisms. A novel line of research focusses on the structure and function of disease specific types of alpha-synuclein aggregates derived from patients. We have generated several tools and models that allows studies of abnormal alpha-synuclein in models and human tissue. We work at several levels ranging from protein chemistry, antibody generation, modeling in cells and cultured brain tissue slices to in vivo models of native and transgenic animals and human brain tissue. Most project are collaborative and involves interaction with expert lab in selected fields.
Methods:
Protein expression and purification, chromatography, SDS-PAGE, immunoblotting, molecular biology, qPCR, cell culture of cell lines, primary brain cells and organotypic brain slices, histochemical analyses, animal modeling, behavioral analyses. Microscopic imaging.
The successful applicant is:
The Neurodegenerative Disease Laboratory is seeking enthusiastic and skilled students interested in conducting their bachelor and master studies in the group. Students finding our research of interest are most welcome to contact us for potential projects that often will be associated to active postdoc and Ph.D. projects to ensure a stroing supervision.
Please contact Group Leader Poul Henning Jensen directly, if interested.
