Early neurodegenerative events in Parkinson’s Disease: immune response and consequences in disease progression.
The lab is currently running several projects in the neuroprotective potential of immunomodulatory strategies in Parkinson’s disease, and the role of peripheral immune cells in the disease progression. The projects include analysis of both neurons and immune cells in brain and in peripheral tissue sand correlate the data with the behavior in the animals as to evaluate possible changes in the neurodegenerative process.
We have normally several projects ongoing that can be adequate as Master projects. Come and ask.
Current open projects:
Master project regarding inflammatory response during Parkinson and microglia subtypes.
Master project studying processes of a-synuclein pathology spreading in brain diseases.
The lab uses different rodent models of Parkinson’s disease to understand the changes in neurons that leads to immune response in brain and in periphery. Our lab uses different approaches to understand and modify such response aiming ultimately to find neuroprotective strategies. We use brain surgery, behavioral test and anatomical techniques to study both neurons and glia in the brain. In addition as a complement we also use patients samples (blood) to complement our animal studies. The students in the lab benefit from an interactive environment, which increase the opportunity to learn, improve your project and bring new ideas.
See : Tentillier et al., J. Neurosci. 2016, Phan et al., Sci Rep 2017, Ferreira & Romero-Ramos, Front Cell Neurosci. 2018; Nissen et al., Mov Disord. 2019
Stereotaxic surgery
Behavioral test
Immunohistochemistry
Microcopy analysis and confocal immuno
Stereological quantification of cells in brain
Flow cytometry
Biochemical assays
An enthusiastic dedicated student, with a strong wish to learn neuroscience in an international environment.
Please contact Group Leader Marina Romero-Ramos directly, if interested.
