New publication in PNAS by Jensen lab
PhD student Nanna Møller Jensen and Prof. Poul Henning Jensen recently contributed to the paper “Alpha-synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity” published in Proc. Natl. Acad. Sci.
The publication was made in a broad collaboration between researchers from Qatar, United Arab Emirates, United Kingdom, Germany, Greece, and Denmark, and investigates the temporal development and role of S129-phosphorylation of alpha-synuclein in both model systems and post-mortem human brain samples of Lewy body diseases. In their contribution, the Jensen lab used organotypic slice cultures to demonstrate a temporal increase in S129-phosphorylation of alpha-synuclein aggregates, linked to a change in aggregate morphology, thereby highlighting a putative maturation process for alpha-synuclein aggregates.