New publication in Neuron by Marco Capogna’s Lab
Wen-Hsien Hou & Marco Capogna contributed to the discovery of a novel GABAergic neuron type of the mouse hippocampus associated with sharp wave ripples and memory, in collaboration with Ivan Soltesz’ group, Stanford, published in Neuron.
Sharp wave ripples (SWR) are brief high-frequency electrographic events generated in the hippocampus that are believed to represent a major neuronal feature in episodic memory. However, the cellular circuits underlying SWRs are not well understood. Szabo et al. discovers a GABAergic neuron type of the mouse hippocampus that exhibits high-frequency activity during SWRs while staying silent during theta-rhythm associated behavioral states, hence named as Theta-Off Ripple-On (TORO) cells. This paper also reports that TORO cells are long-distance projecting GABAergic neurons and express muscarinic acetylcholine receptor M2R. They form a circuit with CA3 hippocampus and areas outside the hippocampus such as the septum. This paper suggests the existence of a dedicated GABAergic circuit element that could be important for episodic memory. The project has been in part funded by a Lundbeck Foundation-NIH BRAIN grant to MC and is a collaboration with the group of Ivan Soltesz, Stanford, who led the project.
Szabo et al., Neuron, 2022
Published online 29 April 2022 (link to publication)
Published in print: Neuron 110, 1–19, June 15, 2022