New publication in Neuron by Marco Capogna’s Lab
Wen-Hsien Hou & Marco Capogna contributed to the discovery of a novel GABAergic neuron type of the mouse hippocampus associated with sharp wave ripples and memory, in collaboration with Ivan Soltesz’ group, Stanford, published in Neuron.
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Sharp wave ripples (SWR) are brief high-frequency electrographic events generated in the hippocampus that are believed to represent a major neuronal feature in episodic memory. However, the cellular circuits underlying SWRs are not well understood. Szabo et al. discovers a GABAergic neuron type of the mouse hippocampus that exhibits high-frequency activity during SWRs while staying silent during theta-rhythm associated behavioral states, hence named as Theta-Off Ripple-On (TORO) cells. This paper also reports that TORO cells are long-distance projecting GABAergic neurons and express muscarinic acetylcholine receptor M2R. They form a circuit with CA3 hippocampus and areas outside the hippocampus such as the septum. This paper suggests the existence of a dedicated GABAergic circuit element that could be important for episodic memory. The project has been in part funded by a Lundbeck Foundation-NIH BRAIN grant to MC and is a collaboration with the group of Ivan Soltesz, Stanford, who led the project.
Szabo et al., Neuron, 2022
Published online 29 April 2022 (link to publication)
Published in print: Neuron 110, 1–19, June 15, 2022