In this study, Marie Curie Fellow Asad Jan (Jensen lab) and Alberto Delaidelli from the University of British Columbia in Canada show that pathological alpha-synuclein in Parkinson disease disrupts the homeostatic NRF2 anti-oxidant response. The authors also examined microarray datasets from four different PD cohorts and assessed the significance of alpha-synuclein aggregation in affecting the NRF2 mediated gene regulation in a mouse model of synucleinopathy. The work was performed in collaboration with the Vægter lab at Dept. Biomedicine and the Nyengaard lab at Aarhus University hospital. (Illustration by Mette Richner, Co-first author).

You can read the full article here:

https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-021-01209-3