Frontotemporal dementia is the second most common subtype of neurodegenerative dementia after Alzheimer's disease, and it is characterised by a strong genetic component. Mutations in GRN explain 1–11% of all cases of frontotemporal dementia but age at onset and clinical presentation are variable, even within families. This study identifies a novel genome-wide locus at GFRA2 as a modifier of disease onset and risk in GRN mutation carriers.

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