Valentina will study how does synapses stay healthy
Valentina Villani starts her PhD journey this February. Her project focuses on understanding synaptic autophagy, a crucial mechanism that maintains protein homeostasis at synapses.
Synapses—the connections between neurons—are essential for communication in the brain and for forming long-lasting memories. To keep up with neuronal activity, synapses are highly dynamic, constantly adjusting their structure and function. This flexibility depends on precise quality-control systems that regulate synaptic proteins and selectively remove damaged or dysfunctional components.
Using a combination of super-resolution microscopy and multi-omics analyses, Valentina aims to uncover new insights into how synaptic protein quality is maintained. Her work will shed light on how autophagy, the process by which cells degrade and recycle components, supports memory formation and overall brain health.
By revealing the principles of synaptic protein regulation, Valentina’s research could help us better understand the cellular mechanisms underlying learning and memory—and, potentially, the early changes that occur in neurodegenerative diseases.