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New publication in PNAS by Jensen lab

PhD student Nanna Møller Jensen and Prof. Poul Henning Jensen recently contributed to the paper “Alpha-synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity” published in Proc. Natl. Acad. Sci.

Figure 4 (A). Treatment withα-syn PFFs in a concentration of100 nM for 4 d. Representative images of cells under the different treatments. DAPI was used for nuclear staining. (Scale bar, 10μm.)

The publication was made in a broad collaboration between researchers from Qatar, United Arab Emirates, United Kingdom, Germany, Greece, and Denmark, and investigates the temporal development and role of S129-phosphorylation of alpha-synuclein in both model systems and post-mortem human brain samples of Lewy body diseases. In their contribution, the Jensen lab used organotypic slice cultures to demonstrate a temporal increase in S129-phosphorylation of alpha-synuclein aggregates, linked to a change in aggregate morphology, thereby highlighting a putative maturation process for alpha-synuclein aggregates.

Read publication in PNAS here