With a strong interdisciplinary background in molecular medicine, mathematics, neurophysiology, and circuit neuroscience, Fiona brings a unique perspective to understanding brain function. Her work also incorporates biophysical modelling and the development of novel analytical tools, further broadening her research approach.

Mapping a key structure in the brain’s visual processing pathway

At the core of Fiona’s research lies a fundamental question: How does the brain actively shape its own sensory perception?

During wakefulness, the brain is in constant interaction with the external world, modifying the information we receive and prioritizing what is most relevant based on our experiences, emotions, and immediate needs.

Focusing on the visual system, Fiona investigates how neural circuits at the brain’s first central processing stage—the thalamus—shape the way we see. If the thalamic region connecting the eyes with the cortex, known as the dLGN (dorsolateral geniculate nucleus), is damaged, it results in blindness.

While the dLGN is essential for relaying visual information from the eyes to the cortex, it does far more than simply transmit signals. Its activity is modulated by factors such as attention, arousal, and past experiences, which can influence visual perception even before the information reaches conscious awareness. Yet, the precise mechanisms underlying this modulation remain largely unknown.

Up and running from August

Using virus-based anatomical tools, large-scale physiological recordings, and high-resolution in vivo light microscopy, Fiona’s lab will investigate how different brain regions interact with the dLGN to shape visual perception. By uncovering the structure and function of these intricate neural circuits, she hopes to gain deeper insight into the foundations of cognition itself.

"I am thrilled to start my research group at DANDRITE, in an environment of inspired and open-minded colleagues. I look forward to all aspects of this new endeavor—from experimental planning and student supervision to sharing fascination and making new discoveries," Fiona explains.

Interim director Poul Henning Jensen elaborates on the strategic significance of the recruitment of Fiona:

”I am very happy that we succeeded in recruiting Fiona for several reasons. Her research topic of how we as individuals interpret the light that hits our eyes, in essence our visual input, is inherently fascinating. Methodologically, her strong neurocircuitry background complements the expertise of our current four group leaders thereby giving us a stronger experimental palette. Finally, Fiona’s solid background in mathematics and computational neuroscience will facilitate integration of novel computational approaches across DANDRITE and bring important learning to our students.”

Fiona joins us from her postdoctoral position at the Institute of Molecular and Clinical Ophthalmology (IOB) in Basel. She will officially begin her role at DANDRITE in August.

Fiona is the fifth Group Leader of the second cohort, thus completing the full team.

• Connect with Fiona on LinkedIn