Nykjær Group

Nykjær Group - Receptor Biology


Using transgenic animal models the Nykjær group is studying sortilin receptors in cellular sorting/trafficking, trans-synaptic communication, and neuronal development and signaling.

Research focus

Research activities are focused towards the functional characterization of a family of neuronal type-1 receptors denoted sortilins, comprising sortilin, SorLA, and SorCS-1, -2, and -3. Although expression predominates in neurons, receptors are also present in specialized cell types outside the nervous system. They bind a vast number of ligands spanning from neurotrophic factors, Alzheimer precursor protein (APP), and progranulin to lipoproteins, implying critical roles in regulation of neuronal survival, differentiation, and cholesterol metabolism. Indeed, a number of genetic association studies and gene targeting in mice have linked sortilin dysfunction with neurodegenerative disorders, ADHD, schizophrenia, bipolar disorder, hypercholesterolemia and diabetes.

Using transgenic mouse models and a broad repertoire of molecular, cellular and genetic tools it is the goal to unravel the function of the receptor family in health and disease and to evaluate their potential as drug targets.

Available projects

The Nykjær group currently has projects available for Master students and postdocs within the following research areas.

Functions of the sortilin receptor family in health and disease:

Signaling by neurotrophic factors
Synaptic plasticty and psychiatric disorders
Axonal development and ADHD
Neurodegeneration
Neuropathic pain
Functionality of the dopaminergic system
Olfactory system
Metabolism


Please contact Group Leader Anders Nykjær directly, if interested.

News

2018.07.12 | People

Andreas Jespersen is new ERASMUS intern in Nykjær Group

Andreas joins us from Imperial College London as new ERASMUS intern in Anders Nykjær's group per June 18th and for the following 3 months until the end of September. He will be assisting Dr. Alena Salasova in her work on the role of Sorcs2 in the development of midbrain dopaminergic neurones, using mice and fish as models.

2018.05.17 | People

Majbritt is a new Laboratory Technician in Anders Nykjær’s group per May 16th.

Majbritt will take over many of Anja’s tasks while she is on maternity leave. Also Majbritt will be working together with postdoc Alena Salasova on her project, investigating the function of SorCS2 during embryogenesis with a particular focus on development of midbrain dopaminergic neurons. Majbritt has an education as a technician and a master…

2018.05.14 | Research news

Group Leader Anders Nykjær contributes to new publication

Frontotemporal dementia is the second most common subtype of neurodegenerative dementia after Alzheimer's disease, and it is characterised by a strong genetic component. Mutations in GRN explain 1–11% of all cases of frontotemporal dementia but age at onset and clinical presentation are variable, even within families. This study identifies a…

2018.05.14 | People

Marianne Lundsgaard Kristensen is new Research Assistant in Nykjær Group

Marianne is new Research Assistant in Anders Nykjær's group per May 15th.  After finishing her master degree at the Institute of Biomedicine, she now got the opportunity to do exciting research at Prof. Anders Nykjær group. Her research will focus on development of blood vessels in the brain of the SORCS1 knockout…

Picture of Alena Salasova

2018.05.07 | People

We welcome Alena Salasova who started as postdoctoral researcher on May 1

Alena will be working in Anders Nykjær's group where she will investigate the function of SorCS2 during embryogenesis with a particular focus on development of midbrain dopaminergic neurons. She will take advantage of multiple tools including biochemical assays, CRISPR/Cas9 technology, RNA scope in situ hybridization, and confocal microscopy, and…

2018.04.12 | AndersNykjær

New postdoc in Nykjær Group

Dongik Park started as postdoc in Nykjær Group on 1 April. He will be investigating the role of sortilin in emotion and memory using various cellular, biochemistry techniques and behaviour analyses. The studies will provide deeper understandings on ethology of affect disorders and their therapeutic treatment.

2018.04.03 | Research news

Official Inauguration of PROMEMO on 4 April 2018

The official inauguration of PROMEMO - Center for Proteins in Memory - a Danish National Research Foundation Center of Excellence will take place on 4 April 2018. The research center PROMEMO started on 1 December 2017 and aims to identify and understand the function of memory associated proteins that determines the persistence of a memory.

2018.02.13 | People

Jeppe Tranberg-Jensen is new bachelor student in Nykjær Group

Jeppe Tranbjerg-Jensen is a new bachelor student in Anders Nykjær group from February 1st. During the next 6 months, he will study axon outgrowth in primary motor neuron cultures and mice embryos to characterize the role of the receptor, SorCS2, in motor neuron development.

2018.02.08 | Awards

Anders Nykjær recieves DKK 15 mio. from the Lundbeck Foundation

Anders receives DKK 15 mio for the 5-year project "Sortilin - balancing synaptic strength and mood states".

2017.11.27 | People

Anne Kathrine Sørensen is new Research year student at Nykjær Group

Anne Kathrine Sørensen started as a research year student in Anders Nykjær’s group per 16 October 2017. For the next year, she will focus on the recently identified Multiple Sclerosis risk gene, SORCS3, studying the expression in the mouse brain, the connection to oligodendrocyte cell-linage, and the phenotype in KO mice. The aim is…

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