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Nykjær Group

Nykjær Group - Receptor Biology


Using transgenic animal models the Nykjær group is studying sortilin receptors in memory, trans-synaptic communication and signaling.

Research focus

Research activities are focused towards the functional characterization of a family of neuronal type-1 receptors denoted sortilins, comprising sortilin, SorLA, and SorCS-1, -2, and -3 with particular emphasis on their role in memory formation and recall, and in emotional regulation. Sortilins bind a vast number of ligands including neurotrophic factors, synaptic proteins, Alzheimer precursor protein (APP), and progranulin implying critical roles in regulation of neuronal survival, differentiation and integrity, and in synaptic plasticity. Indeed, a number of genetic association studies and gene targeting in mice have linked dysfunction of the sortilin receptors with neuropsychiatric and degenerative diseases including ADHD, schizophrenia, bipolar disorder, Alzheimer’s Disease, and frontotemporal lobar dementia.

Using transgenic mouse models, a broad repertoire of molecular, cellular and genetic tools, electrophysiology, mouse behavior, and confocal and two-photon microscopy it is our goal to unravel the function of the receptor family in health and disease and to evaluate their potential as drug targets.  

Available projects

The Nykjær group currently has projects available for Master students and postdocs within the following research areas.

Functions of the sortilin receptor family in health and disease:

  • Synaptic plasticity, memory, and psychiatric disorders
  • Functionality of the dopaminergic system

Please contact Group Leader Anders Nykjær directly, if interested.

News

Fig. 7

From: WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis.

2019.04.26 | Research news

New discovery: The journey of WNT5A across the developing brain in mice and men

Alena Salasova, a postdoc in Anders Nykjær's group, is co-author of new article published in Nature Communications on April 2 . The paper entitled "WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis" describes a novel mechanism of how is a key morphogen WNT5A secreted from choroid plexus…

2019.04.24 | AndersNykjær

Group leader Anders Nykjær is co-author to new paper in Cell Reports

Protecting neurons from cell death following epilepsy A new paper paper by Malik et al in Cell Reports, coauthored by Anders Nykjaer, demonstrates that the receptor SorCS2 is protective against the brain damage that follows an epileptic seizure. They find that SorCS2 secures proper expression of EEAT3, a transporter that mediates cellular uptake…

2019.02.07 | AndersNykjær

Welcome to new intern Andreaa Udrea

Andreea Udrea is a new intern in Anders Nykjær’s group per January 28th. Andreea is a technician and has been working at Copenhagen University before she started her professional bachelor’s degree in chemical and biotechnical technology. As a part of her education she will do a 20-week internship in Anders Nykjær lab, during this time…

Anders Nykjær

2019.01.08 | AndersNykjær

Anders Nykjær interviewed for TV 2

In the interview, Anders Nykjær addresses the influence of smartphones on memory and the importance of continuously challenging the brain in order to strengthen memory.

Picture of Lone Fuglsang Pedersen

2019.01.07 | AndersNykjær

Lone Fuglsang Pedersen is new Research Assistant in Nykjær Lab

Lone Fuglsang Pedersen is new Research Assistant in Anders Nykjær Group. Recently, it was discovered that that sortilin gene family members regulate synaptic transmission between excitatory neurons. Now, Lone and the group will look into excitatory synaptic transmission between excitatory and inhibitory neurons using electrophysiological…

Anders Nykjær

2018.11.02 | Research news

Anders Nykjær interviewed for Nature; "Biomedical ‘ideas powerhouse’ opens its doors in Denmark"

In relation to the inaugurated of the Skou Building in October, Anders Nykjær has been interviewed for Nature, where he, amongst other things, describes how the new Skou building will make a difference; "Moving to the new building will provide an interdisciplinary environment that is critical to address and solve the big questions in neuroscience…

Max Gubert

2018.10.31 | AndersNykjær

Max Gubert is new Research Assistant in Nykjær lab

Max Gubert Olivé is a new research assistant in Anders Nykjær lab and he will be assisting Alena Salasova in her work. He will study developmental aspects of the dopaminergic nervous system.

2018.09.04 | AndersNykjær

Peter Breining is new Postdoc in Nykjær Group

Peter Breining has started as postdoctoral researcher in Nykjaer Group the 1'st September 2018, where he in collaboration with Mads Kjølby will investigate the function of SorCS1 in metabolic disorders with a particular focus on how SorCS1 affects cellular signaling and respiration. He will take advantage of multiple tools including biochemical…

2018.09.04 | SadeghNabavi

Anne Regina Wienand is new shared Research Assistant in Nabavi and Nykjær lab

Anne Regina Wienand will help Mariam to optimize the conditions for the isolation of newly synthesized proteins from cells. This is an important step towards the identification of proteins required for m​emory formation. She would also be introduced to various methods in the Nabavi lab such as stereotaxic surgery and in vivo…

2018.08.29 | AndersNykjær

Linda Rössler is new ERASMUS intern in Nykjær lab

Linda Rössler will be assisting Dr. Dongik Park in his work on the role of the Sortilin receptor in the regulation of emotion and memory using mouse behaviour analyses and primary neuronal culture.

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