The aim of the PhD study was to investigate the role of sortilin in different neuronal subpopulations and its implications in behavior, learning and memory. To accomplish this, Karen Marie generated mice with conditional sortilin deletion in inhibitory or excicatory neurons, respectively. Sortilin deletion was induced selectively in inhibitory neurons of Sort1, Gad2-Cre mice and in excitatory neurons of Sort1, Nex-Cre mice, respectively. Utilizing these mice, she investigated the cell type specific impact of sortilin deletion, and how this affected behavior, synaptic transmission, neuronal network activity and synaptic proteome profile. 

• Read more about the research in Anders Nykjær Lab

Karen Marie Juul Sørensen will continue as a postdoc in Nykjær Lab.