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New postdoc at DANDRITE

2014.10.30 | People

Ingrid Dach started as postdoctoral fellow in Poul Nissen's group in June 2014. Ingrid Dach studies structural and functional details of the transport cycle of the sodium-potassium ATPase. Since the malfunction of this membrane pump is linked to a number of of severe neurological diseases such as familial hemiplegic migraine and rapid-onset…

Schematic illustration of the MhsT transporter, which consists of many thousands of atoms shown here in a surface representation. Red and blue areas are negatively and positively charged, respectively, and grey areas are neutral. The black lines indicate where the protein is located in the cell membrane, and IN and OUT indicate the inside and outside of the cell. The enlarged panel shows the MhsT surface in a semi-transparent version, so you are viewing a centrally located Na+ ion that, in a crystallised state, achieves entry to the inside of the cell through a narrow tunnel, which opens when the transporter slams completely into the outside. The Na+ ion can now escape and, because the intracellular environment has a very low content of Na+, this drives the transporter to transport into the cell – in this case with amino acids and, for the closely related neurotransmitter transporter, with neurotransmitters from the synaptic cleft. (Figure produced by Lina Malinauskaite)

New knowledge about neurotransmitter pathways in the brain

2014.10.28 | Research news

Insight into transport mechanisms in brain cells is extremely important in connection with disorders such as schizophrenia, epilepsy and depression, as well as in connection with producing the right medicine. Defects in proteins responsible for the transport of neurotransmitters are actually related to psychological and neurological disorders, and…

New master student at DANDRITE

2014.10.27 | People

Anne Kathrine Isager started her master studies in Group Leader Poul Henning Jensen's group on 20 October 2014. Anne Kathrine Isager will be working with the secretion of mutated alpha-synuclein in cell culture and primary culture in relation to Parkinson’s Disease. This could help clarify the secretion and thereby spread of alpha-synuclein and…

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Application deadlines 4 times each year (next deadline November 2014).


        



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Revised 2014.10.29

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