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Jensen Group

Jensen Group - Neurodegenerative Disease Laboratory


Our group is interested in understanding how alpha-synuclein contributes to the neurodegenerative processes in Parkinson’s disease, Lewy body dementia and multiple systems atrophy, which are hallmarked by the development of intracellular aggregates of alpha-synuclein. This is investigated in studies of alpha-synuclein aggregates in vitro, in cell models, transgenic animals and human tissue and involves development of new aggregate selective tools.

Research focus


The aim is to decipher how cells regulate their pools of alpha-synuclein species and how they respond to misfolded alpha-synuclein with respect to cytotoxic and protective mechanisms that can be targeted by therapy. This involves proteostatic mechanisms like autophagy, unconventional secretion, prion-like intercellular propagation and homeostatic cellular mechanisms being offset by alpha-synuclein aggregates.

Currently specific projects focuses on alpha-synucleins role in calcium regulation, kinase pathways regulating alpha-synuclein turn-over and toxicity, relation to the innate immune system and implementation of a mouse model for prion-like spreading of alpha-synuclein brain pathology.

Available projects


The Jensen group currently has projects available for Master and PhD students. Please contact Group Leader Poul Henning Jensen directly, if interested.

News

Picture of Lasse Reimer, Poul Henning Jensen, Kostas Vekrellis, and Peter Bross

2019.06.17 | People

Lasse Reimer from Jensen group defended his PhD thesis succesfully on Friday 14 June

Title of Lasse's thises is: ”Inflammation activated kinase PKR directly targets disease-modifying residues within alpha-synuclein and tau for phosphorylation”. The project gives novel insight into the connection between brain inflammation and neurodegerative disorders.

Group photo from Sara’s farewell gathering.

2019.06.13 | PoulHenningJensen

Farewell to Sara Elfarrash. Bon voyage to Mansoura, Egypt

DANDRITE wishes Sara Elfarrash all the best. Sara has been part of Poul Henning Jensen's group since 2016 as research assistant and visiting PhD student. Now she is going to finish her PhD back in Egypt. Bon voyage to Mansoura, Egypt.

Marina Vidotto

2019.06.03 | PoulHenningJensen

Please welcome Marina Vidotto who is new intern in Poul Henning Jensen's group

Marina is a student from Italy where she studies Biotechnology at the second year in Udine University. Marina is going to be part of the group for four months from June onwards.

2019.05.22 | Research news

Postdoc Fikret Emre Kapucu is co-authoring a chapter in the new book "In Vitro Neuronal Networks"

The chapter "Advances in Human Stem Cell-Derived Neuronal Cell Culturing and Analysis" in the new book "In Vitro Neuronal Networks - From Culturing Methods to Neuro-Technological Applications" is co-authored by postdoc Fikret Emre Kapucu from Poul Henning Jensen's group. The chapter provides an overview of the current stage of human in vitro…

A picture of Assistant professor Nelson Ferreira.

2019.03.18 | PoulHenningJensen

Assistant Professor, Nelson Ferreira, publishes a review in International Journal of Molecular Sciences

Nelson Ferreira has recently published a review in the International Journal of Molecular Sciences entitled: “Uncovering the Neuroprotective Mechanisms of Curcumin on Transthyretin Amyloidosis”. The work was performed in collaboration with researchers from the Molecular Neurobiology Group, IBMC- Institute for Molecular and Cell Biology, University…

Photo: Asad Jan

2019.02.11 | PoulHenningJensen

Postdoc and AIAS fellow Asad Jan is co-author on new review article

The article entitled: "Translational control in brain pathologies: biological significance and therapeutic opportunities" has recently been publisted in Acta Neuropathologica.

Photo: Nelson Ferreira

2019.02.04 | People

Congratulations to Nelson Ferreira, who has been appointed Assistant Prof. in Jensen Group

Nelson Ferreira has been appointed as Assistant Professor for 2 years in Group Leader Poul Henning Jensen's group starting January 15th 2019. Nelson Ferreira will be working towards the understanding of the molecular mechanisms underlying neurogeneration in Parkinson's Disease (PD), in particular the self-perpetuating seeded aggregation and…

2018.11.05 | PoulHenningJensen

Lixiang Jiang is a new PhD student in Jensen Group.

As a new PhD student in Jensen Group, Lixiang Jiang, will be working on a project Regulation of α-synuclein transcription by the PLK-2/GSK-3β signalling pathway – a potential modulator of Parkinson’s disease risk.

Alexander Asferg

2018.10.31 | PoulHenningJensen

Alexander Asferg is new student in Jensen Group

Alexander is a Bachelor student in Molecular Biology and has joined the Jensen Group for his bachelors project. He is currently working with the AIAS Fellow Asad Jan, who is developing suitable genome editing tools to block the prion-like spread of alpha-synuclein in vivo.  Alexander is assisting in the preliminary work on this project.

2018.10.30 | PoulHenningJensen

Jensen Group receives 350,000 DKK from Parkinsonforeningen (The Parkinson's Foundation)

The grant is assigned to "investigate whether attempts to increase neurons cytosolic calcium levels protect a mouse model of progressive Parkinson’s disease – Effects of SERCA inhibition and activation of calcium channels."

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