Jensen Group

Jensen Group - Neurodegenerative Disease Laboratory

Our group is interested in understanding how alpha-synuclein contributes to the neurodegenerative processes in Parkinson’s disease, Lewy body dementia and multiple systems atrophy, which are hallmarked by the development of intracellular aggregates of alpha-synuclein. This is investigated in studies of alpha-synuclein aggregates in vitro, in cell models, transgenic animals and human tissue and involves development of new aggregate selective tools.

Research focus

The aim is to decipher how cells regulate their pools of alpha-synuclein species and how they respond to misfolded alpha-synuclein with respect to cytotoxic and protective mechanisms that can be targeted by therapy. This involves proteostatic mechanisms like autophagy, unconventional secretion, prion-like intercellular propagation and homeostatic cellular mechanisms being offset by alpha-synuclein aggregates.

Currently specific projects focuses on alpha-synucleins role in calcium regulation, kinase pathways regulating alpha-synuclein turn-over and toxicity, relation to the innate immune system and implementation of a mouse model for prion-like spreading of alpha-synuclein brain pathology.

Available projects

The Jensen group currently has projects available for Master and PhD students. Please contact Group Leader Poul Henning Jensen directly, if interested.


2018.07.03 | People

Marie Vestergaard is new Bachelor Student in Jensen Group

Marie Vestergaard is new Bachelor Student in Jensen Group. She will be working with immunohistochemistry and Proximity Ligation assay on different types of tissues.

2018.07.02 | People

Andreas Baun is new Bachelor Student in Jensen group

Andreas Baun is new Bachelor Student in Jensen Group. He will work on a project comparing alpha-synuclein aggregates generated under different conditions biochemically and also analyze differences in toxicity on cells.

2018.05.01 | People

Golshah Ayoubi is new Laboratory Technician in Jensen Group

Golshah is new Laboratory Technician in Poul Henning Jensen's Group from 23rd of April. Please give her a warm welcome.

2018.02.05 | PoulHenningJensen

Nanna Møller Jensen is new master student in Jensen Group

Nanna is a Master student in Molecular Medicine and will be part of Poul Henning's research group for the next 1,5 years. Here, she will primarily be working with organotypic brain slices as an in vitro model for Parkinson's disease in order to investigate the characteristics of alpha synuclein spreading.

2018.01.15 | People

Nelson Ferreira has been prolonged for 1 year as postdoc in Jensen Group

Nelson Ferreira will be responsible for overseeing the mouse colonies in Poul Henning Jensen’s group apart from continuing his current postdoctoral research on in vivo prion-like spreading of α-synuclein dependent neuropathology and the molecular basis for development of strains associated to different α-synucleinopathies.

2018.01.08 | Awards

Poul Henning Jensen receives DKK 3,8 millions from The Michael J. Fox Foundation

Poul Henning receives the grant for his research on Parkinson's disease. Please read the entire news story here (only in Danish).

2017.11.28 | Awards

AIAS fellow Asad Jan receives Postdoctoral Fellowship from Lundbeckfonden

AIAS fellow Asad Jan receives postdoctoral fellowship award, in the form of running costs amounting DKK 900,000 from Lundbeckfonden over 3 years, to apply genome editing in a mouse model of Parkinson disease. The project will target the genetic makeup of spinal cord neurons using viral vectors in order to prevent the prion-like propagation of…

2017.10.26 | Awards

Prof. Poul Henning Jensen receives DKK 261.000 from Bjarne Saxhofs Foundation facilitated by the Parkinsons Association

Poul Henning Jensen receives DKK 261.00 for the project: "Mechanistic investigation of the neuroprotective effect of caffeine in prion-like alpha-synuclein models – identification of therapeutic targets".

2017.10.12 | People

Fikret Emre Kapucu is new postdoc in Jensen Group

Fikret Emre Kapucu is new postdoc in Poul Henning Jensen's group from October 1st. Having a long-time research experience on developing analysis methods for electrophysiological signals, he will work on the impacts of the intracellular protein aggregation on neuron structure and functionality. In particular, he…

2017.09.27 | People

Asad Jan is new AIAS Fellow affiliated DANDRITE

Asad Jan is new AIAS Fellow affiliated Poul Henning Jensen's group from October 1st. He completed his professional studies in Clinical Medicine (2005), followed by a doctoral thesis in Neuroscience at the École Polytechnique Fédérale de Lausanne (EPFL), Switzerland (2010). Before joining AIAS (2017) as a junior fellow, he was a…

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