Jensen Group

Jensen Group - Neurodegenerative Disease Laboratory

Our group is interested in understanding how alpha-synuclein contributes to the neurodegenerative processes in Parkinson’s disease, Lewy body dementia and multiple systems atrophy, which are hallmarked by the development of intracellular aggregates of alpha-synuclein. This is investigated in studies of alpha-synuclein aggregates in vitro, in cell models, transgenic animals and human tissue and involves development of new aggregate selective tools.

Research focus

The aim is to decipher how cells regulate their pools of alpha-synuclein species and how they respond to misfolded alpha-synuclein with respect to cytotoxic and protective mechanisms that can be targeted by therapy. This involves proteostatic mechanisms like autophagy, unconventional secretion, prion-like intercellular propagation and homeostatic cellular mechanisms being offset by alpha-synuclein aggregates.

Currently specific projects focuses on alpha-synucleins role in calcium regulation, kinase pathways regulating alpha-synuclein turn-over and toxicity, relation to the innate immune system and implementation of a mouse model for prion-like spreading of alpha-synuclein brain pathology.

Available projects

The Jensen group currently has projects available for Master and PhD students. Please contact Group Leader Poul Henning Jensen directly, if interested.


2018.02.05 | PoulHenningJensen

Nanna Møller Jensen is new master student in Jensen Group

Nanna is a Master student in Molecular Medicine and will be part of Poul Henning's research group for the next 1,5 years. Here, she will primarily be working with organotypic brain slices as an in vitro model for Parkinson's disease in order to investigate the characteristics of alpha synuclein spreading.

2018.01.15 | People

Nelson Ferreira has been prolonged for 1 year as postdoc in Jensen Group

Nelson Ferreira will be responsible for overseeing the mouse colonies in Poul Henning Jensen’s group apart from continuing his current postdoctoral research on in vivo prion-like spreading of α-synuclein dependent neuropathology and the molecular basis for development of strains associated to different α-synucleinopathies.

2018.01.08 | Awards

Poul Henning Jensen receives DKK 3,8 millions from The Michael J. Fox Foundation

Poul Henning receives the grant for his research on Parkinson's disease. Please read the entire news story here (only in Danish).

2017.11.28 | Awards

AIAS fellow Asad Jan receives Postdoctoral Fellowship from Lundbeckfonden

AIAS fellow Asad Jan receives postdoctoral fellowship award, in the form of running costs amounting DKK 900,000 from Lundbeckfonden over 3 years, to apply genome editing in a mouse model of Parkinson disease. The project will target the genetic makeup of spinal cord neurons using viral vectors in order to prevent the prion-like propagation of…

2017.10.26 | Awards

Prof. Poul Henning Jensen receives DKK 261.000 from Bjarne Saxhofs Foundation facilitated by the Parkinsons Association

Poul Henning Jensen receives DKK 261.00 for the project: "Mechanistic investigation of the neuroprotective effect of caffeine in prion-like alpha-synuclein models – identification of therapeutic targets".

2017.10.12 | People

Fikret Emre Kapucu is new postdoc in Jensen Group

Fikret Emre Kapucu is new postdoc in Poul Henning Jensen's group from October 1st. Having a long-time research experience on developing analysis methods for electrophysiological signals, he will work on the impacts of the intracellular protein aggregation on neuron structure and functionality. In particular, he…

2017.09.27 | People

Asad Jan is new AIAS Fellow affiliated DANDRITE

Asad Jan is new AIAS Fellow affiliated Poul Henning Jensen's group from October 1st. He completed his professional studies in Clinical Medicine (2005), followed by a doctoral thesis in Neuroscience at the École Polytechnique Fédérale de Lausanne (EPFL), Switzerland (2010). Before joining AIAS (2017) as a junior fellow, he was a…

2017.09.26 | People

Helene Tallaksen is new bachelor student in Jensen Group

Helene Tallaksen is new bachelor student in Poul Henning Jensen's group from September 4th. She will focus on animal experiments and immunohistochemical analysis of tissue from different animal models of Parkinson’s disease.  ​

2017.08.24 | People

Hjalte Gram is new masterstudent in Jensen Group

Hjalte is new masterstudent in Poul Henning Jensen's group from August 15th. He is going to study  gene expression related to the Calcium changes that are induced by intracellular alpha-synuclein aggregation. The aim is to characterise pathogenic pathways induced by aggretade alpha-synuclein.

Polo-like kinase 2 (PLK-2) phosphorylates an unknown target, which leads to regulation of α-synuclein mRNA by targeting exonal sequences in the gene encoding α-synuclein, SNCA. PLK-2, and other kinases, additionally phosphorylates α-synuclein, which might be involved in the misfolding of the protein and development of toxic protein species such as oligomers and fibrils.

2017.08.09 | Research news

Poul Henning Jensen's group publish finding of novel pathway regulating α-synuclein levels in brain

The title of the paper is: Polo-like kinase 2 modulates α-synuclein protein levels by regulating its mRNA production

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