Simon Glerup

Molecular psychiatry


We study how sortilins contribute to neuropsychiatric phenotypes in humans and animal models, using molecular neurobiology, genetic analysis, in utero electroporation, and mouse behavioral paradigms.

Research Focus

Neurons of the developing brain respond to the extracellular environment in a polarized manner thereby securing the correct neuronal positioning and connectivity in the adult brain. The precise regulation of these processes during development remains poorly understood, but enable us as adults to think, remember, and perceive reality in a normal manner. Their breakdown, on the other hand, manifests itself as mental disorders. My group is particularly interested in a family of sorting receptors, the sortilins, which appear to have evolutionary conserved roles in the establishment and maintenance of neuronal circuits. Our focus is to determine the role of individual sortilins in distinct neuronal systems and how their dysfunction contributes to the behavioural phenotypes observed in psychiatric patients. To study this, we employ a translational strategy using transgenic animal models, in utero electroporation, confocal microscopy, behavioural and molecular neurobiology in addition to genetic and biochemical analysis of patient samples.


Available projects

There are currently projects available for Master and PhD students. Please contact Simon Glerup Pedersen directly for more information, if interested.





News

2018.08.09 | Simon Glerup

Affiliated researcher Simon Glerup has started his own company with fellow researchers, Camilla Gustafsen and Peder Madsen, from institute of Biomedicin.

Affiliated researcher Simon Glerup has started his own company with fellow researchers, Camilla Gustafsen and Peder Madsen, from institute of Biomedicin. The company has set its sight on developing a new type of cholesterol-lowering medicine.  For more information read here. (Only in Danish for now)

2017.10.11 | Awards

DANDRITE Affiliated Researcher Simon Glerup receives prestigious faculty prize

On Wednesday 11 October 2017, Associate Professor and PhD Simon Glerup from the Department of Biomedicine received the faculty's talent prize named after Nobel Prize winner Jens Christian Skou. The prize winner describes himself as a curious nerd who is looking for 'gold' in his research.

2016.03.31 | Research news

Simon Glerup Pedersen receives prestigious grant for research in brain circuit

Simon Glerup Pedersen, Affiliated Researcher at DANDRITE, and his colleagues have just received a big grant of 9.1 mio. DKK from the Lundbeck Foundation. The money will fund basic research into how nerve cell connections are formed. It can lead to new and better treatment and diagnosis of mental disorders, including ADHD. They have found that the…

2015.06.29 | Awards

AU affiliated researcher Simon Glerup is awarded a DFF-starting grant

The Danish Council for Independent Research | Medical Sciences has awarded a Sapere Aude DFF-Starting Grant of DKK 6.61 mio. to AU affiliated researcher Simon Glerup to finance his research in the coming years on "Novel PCSK9 regulatory proteins in the liver and brain".