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Tomonori Takeuchi

Memory selectivity and knowledge updating

Tomonori Takeuchi is a team leader at DANDRITE, an AIAS-COFUND fellow at Aarhus Institute of Advanced Studies (AIAS), and associate professor at Department of Biomedicine, Aarhus University. Tomonori Takeuchi is an expert in the molecular mechanisms of learning and memory. Working with professor Richard Morris at the University of Edinburgh in the UK, he has recently made a ground-breaking finding (Takeuchi et al., Nature, 2016): projections from the noradrenergic locus coeruleus to the hippocampus can drive the novelty-induced memory enhancement via non-canonical release of dopamine.

As part of DANDRITE, he will continue his research aimed at understanding systems-level molecular mechanisms of selective retention of trivial memory through neuromodulation and the assimilation of this retained memory into the relevant knowledge structure, called schema (Tse, Takeuchi et al., Science, 2011), using sophisticated behavioural tests in rats combined with cutting-edge molecular techniques.

Tomonori is the recipient of Novo Nordisk Foundation Young Investigator Award 2017 of DKK 20 million for a seven-year period.

Tomonori Takeuchi’s overall research goal is to understand how memories of everyday events, initially stored in the hippocampus, are ‘selected’ and then ‘assimilated’ into a relevant knowledge structure, called schema, in the neocortex. He comes from Professor Richard Morris’s lab in the UK where he has established himself as an expert on molecular mechanisms of learning and memory. In DANDRITE, he will explore the systems-level molecular mechanisms of selective retention of trivial memory through neuromodulation and the assimilation of this retained memory into the relevant schema, using sophisticated behavioural tests in rats combined with cutting-edge molecular techniques.

News

Trine Rohde

2019.01.08 | People , TomonoriTakeuchi

Please welcome Trine Rohde who is new technician in Tomonori Takeuchi's group

Trine has been a laboratory technician for 12 years and earlier she has worked with molecular biology, physiology and microbiology. In Tomonori's group she will have various job tasks e.g. she will take care of the laboratory's daily operations, she will do different experiments on rats and work in the cell laboratory. Trine is 39 years old and…

Postdoc Kosuke Okuda

2018.12.19 | TomonoriTakeuchi

New postdoctoral researcher in Tomonori Takeuchi’s team

Dr. Kosuke Okuda has been granted DKK 2.1 million (three years) by the Lundbeck Foundation to investigate proteins crucial for novelty-induced memory enhancement. The aim is to identify and functionally charactarize plasticity-related-proteins essential for novelty-induced memory enhancement.  The project will involve: Screening for…

Tomonori Takeuchi

2018.11.19 | Research news, TomonoriTakeuchi

New paper from Tomonori Takeuchi's team

The review paper entitled: "Novelty and Dopaminergic Modulation of Memory Persistence: A Tale of Two Systems" was published in “Trends in Neuroscience” on November 16, 2018. Tomonori Takeuchi - DANDRITE Team Leader - is co-last author on the paper.

Photo: AU

2018.03.09 | People , TomonoriTakeuchi

New Team Leader at DANDRITE - Memory selectivity and knowledge updating

Please welcome Tomonori Takeuchi, who is appointed Team Leader at DANDRITE per 9 March 2018. His team consists so far of Lab Manager Kim Henningsen, Postdoc Mai Iwasaki and himself. Tomonori Takeuchi’s overall research goal is to understand how...

2018.03.08 | People , TomonoriTakeuchi

Mai Iwasaki is new postdoc on Tomonori Takeuchi's team

Mai is new postdoc in Tomonori Takeuchi's team from March 1st. Tomonori's last study showed that when animals are exposed to a completely new environment, the signal of "novelty" emerges in locus coeruleus (LC). Following to that, in newly launched Tomonori's lab here, she would like to identify the further upstream…

2018.01.24 | People , TomonoriTakeuchi

Kim Henningsen is new lab manager at Biomedicine

Kim comes from a background in research, where he has extensive experience with animal models of depression, behavioral tests, and the molecular underpinnings related to these topics. As part of Tomonori Takeuchi’s lab, he will be working with studies focused on elucidating the neuronal background for memory selectivity and knowledge updating.​