Nissen Group


Nissen group - Structural and Functional Studies of Membrane Transporters in Brain


The Nissen group investigates molecular mechanisms of membrane transport processes and biomembrane structure. Activities are mainly focused on protein crystallography, biochemistry, electrophysiology, and include also small-angle X-ray scattering and electron microscopy. Main subjects of research concern P-type ATPase (ion pumps and lipid flippases) and Na+ dependent transporters, but include also structure based drug discovery and protein engineering. 

Research focus


The main focus of our research is to investigate the membrane transporters involved with neurological and psychiatric disorders. The Na+, K+-ATPase is of particular interest, since many neurological disorders are linked to the function of this pump, such as function loss in the Na+,K+-ATPase that can lead to severe diseases such as familial hemiplegic migraine and rapid-onset Dystonia with Parkinsonism.

Several different methods are used to study membrane pumps in our research group, such as structural studies including use of nanodiscs, electrophysiology, and hypoxic conditions.

Available projects

The Nissen group currently has projects available for Master and PhD students. Please contact Group Leader Poul Nissen directly, if interested.

A collection of P-type ATPase structures from the Nissen lab. Figure courtesy of Dr. Oleg Sitsel.

News

Postdoctoral fellow Michael Habeck. 
The crystal structure of Na,K-ATPase with ATP. See text link to download the movie. Credit to Nyblom et al. 2013.

2018.05.31 | Awards

Postdoc Michael Habeck receives Marie Curie fellowship

Postdoc Michael Habeck from Poul Nissen’s group has been awarded a 2 year Marie Curie fellowship from the European Commission, which will begin per 1 June 2018. The fellowship was awarded to conduct structural studies of Na,K-ATPase isoforms and mutants.

2018.04.05 | People

New postdoctoral researcher in Poul Nissen's group

Montana Caballero Bermejo started as postdoctoral researcher in Poul Nissen's group, where she will be working for 2 years as postdoc to study the structure and function of PMCA4b, which is an important plasma membrane calcium pump in brain and other tissues. The studies will involve biochemistry, crystallography, and cryo-electron microscopy.…

2018.04.03 | Research news

Official Inauguration of PROMEMO on 4 April 2018

The official inauguration of PROMEMO - Center for Proteins in Memory - a Danish National Research Foundation Center of Excellence will take place on 4 April 2018. The research center PROMEMO started on 1 December 2017 and aims to identify and understand the function of memory associated proteins that determines the persistence of a memory.

2018.03.05 | News from the management

Poul Nissen continues as appointed director of DANDRITE

We are very happy to announce that core group leader Poul Nissen will continue as the director of DANDRITE, appointed by the executive board. The appointment is for the second 5 year period per 5 March 2018. Poul Nissen was first appointed founding director for one year in 2013 and then as the director for four years in 2014. The leadership will…

2018.03.05 | PoulNissen

New laboratory technician at DANDRITE

Tanja Klymchuk is now affiliated as shared laboratory technician at DANDRITE, sharing her time between the group's of Poul Nissen, Hanne Poulsen, Magnus Kjærgaard, Thomas Boesen, and Assoc. prof. Bjørn Pedersen at the Dept. Molecular Biology and Genetics. Tanja will, together with technician Anna Marie Nielsen, take over some of the duties and…

2018.02.06 | PoulNissen

New master student in Poul Nissen's group

Anne Christine Møller is a new master student in Group Leader Poul Nissen's group. She will be working on a Biotech Engineering project with post doc Azadeh Shahsavar on lipid extractions from pig brains. Comparing different lipid extracts she will investigate activity and structural properties of membrane proteins. She will also investigate…

2018.02.06 | MarkDenham

New publication from Mark Denham's group in collaboration with Poul Nissen

The article is just published in Frontiers. Title: Central and Peripheral Nervous System Progenitors Derived from Human Pluripotent Stem Cells Reveal a Unique Temporal and Cell-Type Specific Expression of PMCAs.

2018.01.26 | Research news

Novo Nordisk Foundation awards DKK 255 million for establishing the world’s most powerful protein “microscope”

The Novo Nordisk Foundation is supporting the establishment of an ultra-modern research platform in Lund, Sweden. The platform will enable researchers to investigate proteins at a level of detail not previously possible and can thus form the basis for developing new drugs. Researchers from Aarhus University have had a strong impact on the…

2018.01.24 | Knowledge exchange

Nordic network in Nobel Prize–winning technology

A new Danish-Swedish research alliance wants to advance understanding of how biological molecules look and behave. With support from the Novo Nordisk Foundation and the Knut and Alice Wallenberg Foundation, scientists at four universities in Denmark and Sweden will join forces to create a Nordic network in cryo-electron microscopy, whose…

2018.01.17 | Awards

Sara Basse receives a PhD Fellowship from the Boehringer Ingelheim Fonds

The stipend will continue Sara's PhD studies with Magnus Kjærgaard and Poul Nissen. She will investigate the structural and mechanistic basis of unidirectional calcium transport through direct visualization by single-molecule FRET and FRET-guided crystallization of key intermediates, and she will establish techniques for…

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