Nissen Group


Nissen group - Structural and Functional Studies of Membrane Transporters in Brain


The Nissen group investigates molecular mechanisms of membrane transport processes and biomembrane structure. Activities are mainly focused on protein crystallography, biochemistry, electrophysiology, and include also small-angle X-ray scattering and electron microscopy. Main subjects of research concern P-type ATPase (ion pumps and lipid flippases) and Na+ dependent transporters, but include also structure based drug discovery and protein engineering. 

A collection of P-type ATPase structures from the Nissen lab. Figure courtesy of Dr. Oleg Sitsel.

Research focus


The main focus of our research is to investigate the membrane transporters involved with neurological and psychiatric disorders. The Na+, K+-ATPase is of particular interest, since many neurological disorders are linked to the function of this pump, such as function loss in the Na+,K+-ATPase that can lead to severe diseases such as familial hemiplegic migraine and rapid-onset Dystonia with Parkinsonism.

Several different methods are used to study membrane pumps in our research group, such as structural studies including use of nanodiscs, electrophysiology, and hypoxic conditions.

Available projects

The Nissen group currently has projects available for Master and PhD students.
Please contact Group Leader Poul Nissen directly, if interested.

See here the poster presentation of research projects in Poul Nissen's laboratory.

News

Structural representation of the crystal structure of the protein kinase RSK2

2018.10.19 | Research news

Study of a blockbuster drug mechanism published in Nature Communications by Nissen group

Nissen group and co-authors have published a study on a crystal structure and inhibitory mechanism of dimethyl fumarate bound to the protein kinase RSK2.

2018.10.12 | Events

New exhibition at the Steno Museum ‘Profession and Passion – a Life in Science’

The heart of the exhibition is the Nobel Prize laureate Jens Chr. Skou’s office and the main focus is his sodium-potassium pump. Together with five other researchers’ workplaces and their stories, Jens Chr. Skou’s office comprises the basis of the exhibition. Poul Nissen and his group exhibit as part of the story behind Skou. Poul is represented…

Poul Nissen presenting at the Nordic EMBL Partnership Meeting. Photo by Øystein Horgmo, University of Oslo.

2018.10.01 | Research news

New speaker for the Nordic EMBL Partnership for Molecular Medicine

The Nordic EMBL Partnership is very pleased to announce that Professor Poul Nissen, Director of DANDRITE (Danish Research Institute of Translational Neuroscience) has been named as the third speaker of the Nordic EMBL Partnership.

2018.09.26 | PoulNissen

New student assistant in Poul Nissen’s group

Jonathan Søholm-Boesen has started as new student assistant in Poul Nissen’s group on 3 Sept. 2018, where he will assist Jesper L. Karlsen on web related updates.  

2018.09.19 | PoulNissen

Mads Eskesen Christensen is new Master Student in Nissen Group

Mads Eskesen Christensen works on a project, which aims to establish protocols to reconstitute Na,K-ATPase in liposomes as well as lipid-protein nanoparticles for subsequent structural and functional studies by single molecule fluorescence and electron microscopy.

2018.09.17 | PoulNissen

Line Marie Christiansen is new Research Assistant in Nissen Group

Line Marie Christiansen will work with the P-type ATPases, in particular the P4-ATPases also known as lipid flippases. The membrane-protein group is linked to several neurological diseases, although the connection is not well understood yet. Based on a structural and functional approach the project aims to help gain a better understanding of the…

2018.09.03 | PoulNissen

POUL NISSEN AWARDED THE CARLSBERG FOUNDATION RESEARCH PRIZE 2018

Poul Nissen receives the Carlsberg Foundation Research Prize for his groundbreaking work in structural biology. The prize was given by HRH the Crown Princess, Minister of Higher Education and Science, Tommy Ahlers, and chairman of the Carlsberg Foundation, Flemming Besenbacher, as part of the annual banquet at the New Carlsberg Glyptotek on Sunday…

Postdoctoral fellow Michael Habeck. 
The crystal structure of Na,K-ATPase with ATP. See text link to download the movie. Credit to Nyblom et al. 2013.

2018.05.31 | Awards

Postdoc Michael Habeck receives Marie Curie fellowship

Postdoc Michael Habeck from Poul Nissen’s group has been awarded a 2 year Marie Curie fellowship from the European Commission, which will begin per 1 June 2018. The fellowship was awarded to conduct structural studies of Na,K-ATPase isoforms and mutants.

2018.04.05 | People

New postdoctoral researcher in Poul Nissen's group

Montana Caballero Bermejo started as postdoctoral researcher in Poul Nissen's group, where she will be working for 2 years as postdoc to study the structure and function of PMCA4b, which is an important plasma membrane calcium pump in brain and other tissues. The studies will involve biochemistry, crystallography, and cryo-electron microscopy.…

2018.04.03 | Research news

Official Inauguration of PROMEMO on 4 April 2018

The official inauguration of PROMEMO - Center for Proteins in Memory - a Danish National Research Foundation Center of Excellence will take place on 4 April 2018. The research center PROMEMO started on 1 December 2017 and aims to identify and understand the function of memory associated proteins that determines the persistence of a memory.

Showing results 1 to 10 of 50

1 2 3 4 5 Next