Nykjær Lab uncovers a new mechanism that helps motor neurons to develop and regenerate
In a newly published article in Cell Reports authors from Nykjær Lab describe how SorCS2 receptor determines the motor neuron identity, motor nerve outgrowth, and synapse architecture.
The study recently published in Cell Reports provides novel insights into how motor neurons communicate during neurodevelopment and after injury. The authors identify the SorCS2 receptor as an important player for motor neuron identity, motor nerve outgrowth, and synapse architecture.
They describe how SorCS2 receptor determines the motor neuron identity, motor nerve outgrowth, and synapse architecture in both zebrafish and mice. When they reduced the levels of SorCS2 in fish, it affected how the nerves connect to muscles and how the fish move. In mice, they found that SorCS2 is important for making sure motor neurons develop correctly and regenerate if they get damaged.
These findings might be important for patients suffering from neurological disorders or trauma.
Assistant Professor Alena Salasova and Professor Anders Nykjær are the corresponding authors.
The article is published in Cell Reports.