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Nykjær Group

Receptor Neurobiology

Research activities are focused towards the functional characterization of a group of type-1 receptors denoted the Vps10p-domain family, or so-called sortlins, that comprises sortilin, SorLA, and SorCS-1, -2, and -3. The receptors are enriched in neurons where they mediate trafficking and signaling of a vast number of ligands such as neurotrophic factors along with their cognate receptors, neurotransmitter receptors, APP, and progranulin. Among many activities, the receptors regulate neuronal cell fate, differentiation, innervation, synaptic plasticity, and learning and memory. Key goals of the Nykjaer lab is to understand their functions in the heathy brain, dissect out their mode of actions, investigate how genetic variation contributes to disease development - in particular of neuropsychiatric disorders and memory impairment -, and to evaluate their potential as drug targets.

Methodologies include transgenic mice and zebrafish, a broad repertoire of molecular, cellular and genetic and viral tools, transcriptomics and (phospho)proteomics, neuroembryology, mouse behavior, electrophysiology and advanced imaging including high-resolution microscopy. In vivo fiber photometry and mesoscale single unit recordings are currently being implemented.

Available projects 

The Nykjær group currently has projects available for Master students and postdocs within the following research areas. 

Functions of the sortilin receptor family in health and disease:

  • Molecular mechanisms underlying memory and psychiatric disorders

Please contact Group Leader Anders Nykjær directly, if interested.

News

Previous news from the research group

News

2018.04.03 | Research news

Official Inauguration of PROMEMO on 4 April 2018

The official inauguration of PROMEMO - Center for Proteins in Memory - a Danish National Research Foundation Center of Excellence will take place on 4 April 2018. The research center PROMEMO started on 1 December 2017 and aims to identify and understand the function of memory associated proteins that determines the persistence of a memory.

2018.02.13 | People

Jeppe Tranberg-Jensen is new bachelor student in Nykjær Group

Jeppe Tranbjerg-Jensen is a new bachelor student in Anders Nykjær group from February 1st. During the next 6 months, he will study axon outgrowth in primary motor neuron cultures and mice embryos to characterize the role of the receptor, SorCS2, in motor neuron development.

2018.02.08 | Awards

Anders Nykjær recieves DKK 15 mio. from the Lundbeck Foundation

Anders receives DKK 15 mio for the 5-year project "Sortilin - balancing synaptic strength and mood states".

2017.11.27 | People

Anne Kathrine Sørensen is new Research year student at Nykjær Group

Anne Kathrine Sørensen started as a research year student in Anders Nykjær’s group per 16 October 2017. For the next year, she will focus on the recently identified Multiple Sclerosis risk gene, SORCS3, studying the expression in the mouse brain, the connection to oligodendrocyte cell-linage, and the phenotype in KO mice. The aim is…

2017.09.05 | Research news

New publiction by team leader Arne Möller and colleagues

The title of the paper is: Hidden Twins: SorCS Neuroreceptors Form Stable Dimers

2017.06.01 | Awards

Prof. Anders Nykjær receives DKK 250.000 from Foundation for Research in Neurology

Anders Nykjær receives DKK 250.000 for the project "Functional characterization of the multiple sclerosis risk gene SORCS3: a novel drug target".

2017.05.10 | Knowledge exchange

Anders Nykjær interviewed for DR Science

On Neuroscience Day 2017, Group Leader Anders Nykjær was interviewed for two articles by DR Science.

2017.05.05 | Awards

DANDRITE researchers receive DFF-Research Project Grants from the Danish Council for Independent Research

Core group leaders Anders Nykjær and Poul Nissen, group leader Sadegh Nabavi and team leader Magnus Kjærgaard are all recipients of research grants from the FNU, FSS and FTP sections of DFF.

Prof. Anders Nykjær

2017.04.19 | Research news

Prof. Anders Nykjær receives DKK 62 million granted to new basic research centre

Professor Anders Nykjær and DANDRITE colleagues have received the grant from the Danish National Research Foundation. The goal is to understand how emotional impressions affect our long-term memory.

2016.11.30 | Research news

Two grants awarded to Anders Nykjaer

Anders Nykjaer was granted DKK 750.000 by the Novo Nordisk Foundation for the project entitled “SorCS1 – boosting energy expenditure in obesity”. He also received a grant from the Danish Multiple Sclerosis Association (Scleroseforeningen) for the project entitled: ”Functional characterisation of the multiple sclerosis risk gene SORCS3."

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