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Jobs and vacancies at DANDRITE

Keep an eye on this website, as we continually advertise open positions here.

If you are looking for study opportunities at DANDRITE, please see here

If you are looking for PhD opportunities at DANDRITE, please see here

2-Year laboratory technician within a stem cell laboratory

The Department of Biomedicine at Faculty of Health at Aarhus University invites applications for a position as a laboratory technician within the Denham group working on human organoids and stem cells as per the 1st of February 2021 or as soon as possible thereafter. The tasks are followed and defined by an external grant. The position will accordingly expire on 31 January 2023. However, there is the possibility for an extension.  

Your job responsibilities

As a laboratory technician, your primary tasks are starting and maintaining cultures of human organoids and human stem cells. The work will include cell culture, general molecular biology methods and immunohistochemistry. Some parts of the project may involve helping with behavioral studies and handling mice and rats. It will also be your responsibility to order materials reagents and performing related administrative work. In your daily work, you have a close interaction with competent colleagues.

Your main tasks will consist of:

  • Long-term culture of human organoids and human pluripotent stem cells
  • Cryosectioning and immunostaining
  • Western blotting
  • Production of lentiviruses and plasmid cloning
  • PCR, QPCR and related molecular biology techniques

You will report to Associate Prof. Mark Denham.  

Application deadline is Sunday 3 Jan 2021 at 23:59 CET

You can read more about the position and application here

Postdoc in Stem Cells and Neural Organoids

The Department of Biomedicine at Faculty of Health at Aarhus University invites applications for a position as Postdoc in the field of stem cell biology as per the 1st of March 2021 or as soon as possible thereafter. The position is a 2-year full-time position, with possibility for extension.

The Danish Research Institute of Translational Neuroscience (DANDRITE) is the Danish node of the Nordic EMBL Partnership for Molecular Medicine and is hosted by Aarhus University and funded by the Lundbeck Foundation. DANDRITE is devoted to interdisciplinary approaches in basic and translational neuroscience and is placed at two departments: Department of Biomedicine (Faculty of Health) and Department of Molecular Biology and Genetics (Faculty of Natural Sciences).

About the research project
A funded two-year postdoctoral position, is available from March 2021, in Mark Denham’s research group. The Denham group work on understanding how the human nervous system develops and applying this knowledge to developing stem cell therapies for diseases such as Parkinson’s disease. Specifically, the group works on developing protocols for generating cultures containing specific neuronal subtypes and the production of complex organoid culture systems that recapitulate in vivo developmental processes. The purpose of the postdoc is to develop human neural organoids from various brain regions and to characterise their cellular composition and neuronal activity using various methods including microelectrode array and single-cell sequencing, respectively.  

Your job responsibilities
As Postdoc your position is primarily research-based but may also involve teaching assignments. You will contribute to the development of the department through research of high international quality. In your daily work, you will work closely with colleagues on your project, where you will receive supervision and guidance.

Your main tasks will consist of:

  • Independent research of high international quality, including publication.
  • The culture, development and analysis of neural organoids.

You will report to the Associate Professor Mark Denham.  

Application deadline is 7 December.

You can read more about the position and application here

Jobs and vacancies at AU

Two postdoc positions in studies of protein trafficking and cellular adhesion

About the research group

The laboratory of associate professor Lene N. Nejsum, Department of Clinical Medicine, Aarhus University, Denmark, focuses on epithelial cell biology in health and disease. We are especially interested in AQP water channels and the regulation of AQP2 vesicles shuttling as well as how AQPs regulate cell-cell adhesion via modulation of junctional proteins.

About the research projects

You will be joining one of the following research projects:

Protein trafficking of renal AQP2:

In this position (#1), the postdoctoral candidate will be part of a team that will investigate the underlying mechanisms of protein trafficking via vesicle shuttling of renal AQP2, which plays a vital role in regulation of body water balance via fine-tuning of urine concentration. The project is especially focused on using cell culture and new bioimaging techniques to investigate the vesicular population of AQP2. The position will include an international stay.

Investigations of the role of AQP3 in cellular adhesion in cancer:

In this position (#2), the postdoctoral candidate will be part of a team investigating how AQP3 affects cellular adhesion in cancer. This will be done via various cell biological methods, assays for cancer cell adhesion and invasion as well as in animal models. The project will focus on multiple myeloma.   

If you are interested in the upcoming position, please contact associate professor Lene N. Nejsum (nejsum@clin.au.dk).

You can read more about the position and how to apply here

Structural and functional studies of glucosylceramide transporters

Applications are invited for a PhD fellowship/scholarship at Graduate School of Natural Sciences, Aarhus University, Denmark, within the Molecular Biology and Genetics programme. The position is available from 1 May 2021 or later.

Structural and functional studies of glucosylceramide transporters.

Research area and project description:
Research area: Structural Biology

P4-ATPases, a subgroup of the ATP driven P-type ATPases transporter family, are lipid transporters in secretory and plasma membranes. Recently, the lipid flippase ATP10B has been reported to transport glucosylceramide (GluCer) in lysosomes. Parkinson’s Disease (PD) associated mutations in ATP10B disturb the lysosomal export of GluCer, which may result in toxic lysosomal substrate accumulation and/or cytosolic substrate depletion.

While studies and structures of a number of phosphatidylserine specific lipid flippases have identified the binding mode and transport pathway for phospholipids, it is currently unknown how selectivity for GluCer is conferred to ATP10B and how this lipid is transported. To address these questions, we will elucidate mechanisms of substrate binding, transporter function and regulation using biochemical analysis and structural approaches.

The PhD project will involve expression, purification and structural/functional characterization of membrane proteins involved in glucosylceramide transport and homeostasis with a view to understanding their role in neurological disease. Methods learned and used will be cryo-electron microscopy and X-ray crystallography, as well as various biochemical methods to elucidate function.

Application deadline is 1 February 2021 at noon (11.59 AM CEST).  

You can read more about the position and how to apply here 

Postdoctoral position in structural studies of human lipid transporters at Aarhus University

The position:
We're looking for a postdoc to join the newly established Lyons Lab at the Department of Molecular Biology and Genetics, Aarhus University, Denmark. The laboratory's interest is the interplay between structure and function of transmembrane transport processes with a focus on lipid transport systems. The lab houses facilities for mammalian protein production, purification, cellular, biochemical and biophysical characterizations and data processing and has access to the state-of-the-art Cryo-EM facility housed at iNANO (link here). The group is part of the Section of Structural Biology at Aarhus University.

The project is within the framework of a highly prestigious and international collaborative research program ASAP (Aligning Science Across Parkinson’s), the team will explore the structure, function and regulation of the human glucosylceramide transporters (ATP10) (link here). These molecular insights may pave the way for a drug discovery strategy for Parkinson’s disease.

The project:
The candidate will apply single-particle cryo-EM in combination with biochemical, pharmacological and cellular techniques to characterize the human glucosylceramide transporters of the ATP10 family.  

Application deadline is 9 December.

You can read more about the position and application here

Postdoc postion from January at the Department of Biomedicin

Due to unforeseen circumstances a postdoc position has become available at Robert A. Fenton's group.  Robert A. Fenton is Professor of Molecular Cell Biology at the Department of Biomedicine. The position is initially funded for 1 year, but a two year extension is possible for excellent candidates who demonstrate their ability in the position.

The project is cross-disciplinary, so the candidate should either be:

1) Skilled in animal studies (required to characterize a novel model with cell specific in vivo proteome tagging) and general cell biology/molecular biology techniques.

2) Skilled in biochemical techniques (click chemistry, biochemical purifications) and a willingness to learn aspects of protein mass spectrometry.

If you are interested in the position, Robert can be contacted on email: robert.a.fenton@biomed.au.dk

Past job opportunities