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Jensen Group

Neurodegenerative Diseases Laboratory

 

Our group want to understand how neurodegenerative diseases like Parkinson’s disease, Lewy body dementia, and multiple systems atrophy develop, progress, and elicit their many symptoms.

We centre our studies on how the protein alpha-synuclein contributes to these processes because the spread of alpha-synuclein aggregate-pathology in the tissue plays a central role for these diseases. This is investigated in studies of alpha-synuclein aggregates in vitro, in cell models, cultures brain slices, live animals and human tissue and involves development of new tools and models.

Research focus

Our aims are: 1) Decipher how cells regulate their pools of alpha-synuclein species because elevated levels represents a risk factor for disease with projects both at the regulation of alpha-synuclein transcription and the catabolic pathways for normal and abnormal alpha-synuclein species. 2) Understand how different folding strains of alpha-synuclein aggregates develop and cells respond to such aggregated alpha-synuclein species with respect to cytotoxic and protective mechanisms that can be targeted by therapy. 3) Understand how cells suffering from development of intracellular alpha-synuclein aggregates affects their surrounding tissue and connected neurons contributing to spreading of pathology and development of neurological/psychiatric symptoms.

Currently specific projects focuses on i) alpha-synucleins role in calcium regulation with a focus on calcium pumps in the endoplasmic reticulum and plasma membrane, ii) signalling pathways regulating transcription of alpha-synuclein and degradation of its native and aggregated species, iii) characterization of oligomeric and fibrillar alpha-synuclein aggregates, iv) development and application of proximity ligation assays to uncover novel alpha-synuclein pathology in human brain tissue, v) in vivo mouse studies focussing on modelling and mechanisms involved in disease progression and how they can be inhibited pharmacologically.

Available projects


The Jensen group currently has projects available for Master and PhD students. Please contact Group Leader Poul Henning Jensen directly, if interested.

 

News

Previous news from the research group

News

2018.10.30 | PoulHenningJensen

Jensen Group receives 350,000 DKK from Parkinsonforeningen (The Parkinson's Foundation)

The grant is assigned to "investigate whether attempts to increase neurons cytosolic calcium levels protect a mouse model of progressive Parkinson’s disease – Effects of SERCA inhibition and activation of calcium channels."

2018.09.05 | PoulHenningJensen

Hjalte Gram is new Research Assistant in Poul Henning Jensens' group

Hjalte Gram is employed in Poul-Henning Jensens group as research assistant per 1'st of august 2018. He will work on factors leading to pathological aggregation of a central protein in Parkinson’s disease, a-synuclein, using animal and cell studies.'

2018.07.03 | People

Marie Vestergaard is new Bachelor Student in Jensen Group

Marie Vestergaard is new Bachelor Student in Jensen Group. She will be working with immunohistochemistry and Proximity Ligation assay on different types of tissues.

2018.07.02 | People

Andreas Baun is new Bachelor Student in Jensen group

Andreas Baun is new Bachelor Student in Jensen Group. He will work on a project comparing alpha-synuclein aggregates generated under different conditions biochemically and also analyze differences in toxicity on cells.

2018.05.01 | People

Golshah Ayoubi is new Laboratory Technician in Jensen Group

Golshah is new Laboratory Technician in Poul Henning Jensen's Group from 23rd of April. Please give her a warm welcome.

2018.02.05 | PoulHenningJensen

Nanna Møller Jensen is new master student in Jensen Group

Nanna is a Master student in Molecular Medicine and will be part of Poul Henning's research group for the next 1,5 years. Here, she will primarily be working with organotypic brain slices as an in vitro model for Parkinson's disease in order to investigate the characteristics of alpha synuclein spreading.

2018.01.15 | People

Nelson Ferreira has been prolonged for 1 year as postdoc in Jensen Group

Nelson Ferreira will be responsible for overseeing the mouse colonies in Poul Henning Jensen’s group apart from continuing his current postdoctoral research on in vivo prion-like spreading of α-synuclein dependent neuropathology and the molecular basis for development of strains associated to different α-synucleinopathies.

2018.01.08 | Awards

Poul Henning Jensen receives DKK 3,8 millions from The Michael J. Fox Foundation

Poul Henning receives the grant for his research on Parkinson's disease. Please read the entire news story here (only in Danish).

2017.11.28 | Awards

AIAS fellow Asad Jan receives Postdoctoral Fellowship from Lundbeckfonden

AIAS fellow Asad Jan receives postdoctoral fellowship award, in the form of running costs amounting DKK 900,000 from Lundbeckfonden over 3 years, to apply genome editing in a mouse model of Parkinson disease. The project will target the genetic makeup of spinal cord neurons using viral vectors in order to prevent the prion-like propagation of…

2017.10.26 | Awards

Prof. Poul Henning Jensen receives DKK 261.000 from Bjarne Saxhofs Foundation facilitated by the Parkinsons Association

Poul Henning Jensen receives DKK 261.00 for the project: "Mechanistic investigation of the neuroprotective effect of caffeine in prion-like alpha-synuclein models – identification of therapeutic targets".

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