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Christian Vægter

PNS neuron-glia interactions in health and disease - implications in Pain and Regenerative Processes 

The peripheral sensory neurons are completely covered by glial cells, with satellite glial cells (SCG) covering the neuronal soma and Schwann cells covering the length of the axon. It is therefore obvious that these glia cells play major roles in how the neurons function, and that diseases affecting the glia have dramatic consequences for the functionality of the neurons. 

Our aim is to understand how peripheral glia cells affect neuronal functionality in health but also following nerve injury, in diseases such as diabetes (diabetic neuropathy), or following treatment of cancer by chemotherapeutics (CIPN). Our research span from molecular biology, cells lines and primary cultures, tissue analysis with confocal and electron microscopy to experiments with mice and rats (microsurgery and behavioral analysis).  

On-going research projects encompass the following topics:

  • PNS injury and disease (traumatic injury, diabetes, chemotherapy, inflammation etc)
  • SGC and Schwann cell response on transcriptional and protein level
  • Schwann cell and SGC communication with axons by exosomes 
  • Spinal cord plasticity in pain processes


Left: Electron microscopy image of mouse sciatic nerve visualizing unmyelinated sensory neuron axons (Remak bundle) and myelinated axons. Right: Sensory neurons from mouse dorsal root ganglia (DRG) grown in culture. (figures: Christian Vægter)


Figure 1. Blood-nerve barrier

2019.02.19 | ChristianVægter

Postdoc Nádia Gonçalves from Vaegter's lab published a new review article

Following previous work from 2017 for Nature Reviews Neurology, Vægter group has recently published a review in Frontiers Neuroscience entitled: "Functional and Structural Changes of the Blood-Nerve-Barrier in Diabetic Neuropathy". The work was performed in collaboration with other DANDRITE researchers and the International Diabetic Neuropathy…

Photo of Alana Miranda Pinheiro

2019.01.29 | People

Please welcome Alana Miranda Pinheiro who is new PhD Student in Vægter's group

Alana started in Christian Vægter's group in the beginning of January. It is now well established that injury to peripheral nerves results in activation of SGCs surrounding the soma of the injured neurons. Utilizing in vivo models, Alana will characterize the injury-response of satellite glial cells (SGC) at transcriptional and proteomic level.…

2018.10.01 | ChristianVægter

DANDRITE affiliated researcher, Christian Vægter, receives million grant.

Christian Vægter is part of a consortium of scientists, who has recived 18.4 million DKK. from Innovationsfonden. The grant has been licensed to work on a promising Medicinal product against pain in the nerve paths.  For more information you can click here (Only in Danish) 

2018.08.02 | ChristianVægter

Christian Vægter has been granted DKK 2.6 million from the Independent Research Foundation

Christian Vægter has been granted DKK 2.6 million from the Independent Research Foundation in Denmark to investigate the role of Schwann cell impairment in diabetic neuropathy. Christian will receive the grant over a 3 year period for the project dedicated to explore how Schwann cell derived exosomes impact on axonal homeostasis. You…

2015.06.22 | Awards

AU affiliated researcher Christian Vægter is awarded a DFF-research project grant

The Danish Council for Independent Research | Medical Sciences has awarded a DFF-Research Project Grant of DKK 2.45 mio. to AU affiliated researcher Christian Vægter, which will finance the project "Satellite Glial cells in Nerve Injury – Modulators of Neurotrophic Signaling following Nerve Injury?"