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New publication from Marco Capogna in The Journal of Neuroscience

The article is titled "Control of amygdala circuits by 5-HT neurons via 5-HT and glutamate co-transmission". The autors are Ayesha Sengupta, Marco Bocchio, David M. Bannerman, Trevor Sharp & Marco Capogna.

2017.02.17 | Emilie Marie Niebuhr Aagaard

Figure legend: A) Biocytin-filled principal neuron of the basal amygdala showing a sparse axon with long-projecting branches (left) and spiny dendrites (right). B) Top: example electrophysiological recording of principal neuron spiking. Optical stimulation for 30 s at 20 Hz of 5-HT axons reduced the neuron firing rate. Bottom: Quantification of pooled data. Upper blue stimulation bar denotes optogenetic stimulation.

Abstract: The neuromodulator serotonin (5-HT) gates affective states and regulates fear memory and psychiatric disorders. For this reason, it is important to ascertain the physiological effects of serotonin in emotional brain structures such as the amygdala. To address this question, Sengupta et al. expressed channelrhodopsin in serotonergic neurons of the dorsal raphe nucleus and optically stimulated terminals in the basal amygdala of mouse brain slices. Surprisingly, the optogenetic activation of serotonergic fibers in the amygdala evoked the release of glutamate that excited subsets of interneurons under baseline conditions. However, when the frequency of stimulation of serotonergic fibers increased, as it occurs during reward anticipation and receipt, release of serotonin occurred, which exerted multiple effects and decreased the firing of principal neurons. Thus, 5-HT neurons exert a frequency-dependent, cell type-specific control over amygdala circuitry via 5-HT and glutamate co-release to inhibit the amygdala output

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