Nissen Group


Nissen group - Structural and Functional Studies of Membrane Transporters in Brain


The Nissen group investigates molecular mechanisms of membrane transport processes and biomembrane structure. Activities are mainly focused on protein crystallography, biochemistry, electrophysiology, and include also small-angle X-ray scattering and electron microscopy. Main subjects of research concern P-type ATPase (ion pumps and lipid flippases) and Na+ dependent transporters, but include also structure based drug discovery and protein engineering. 

Research focus


The main focus of our research is to investigate the membrane transporters involved with neurological and psychiatric disorders. The Na+, K+-ATPase is of particular interest, since many neurological disorders are linked to the function of this pump, such as function loss in the Na+,K+-ATPase that can lead to severe diseases such as familial hemiplegic migraine and rapid-onset Dystonia with Parkinsonism.

Several different methods are used to study membrane pumps in our research group, such as structural studies including use of nanodiscs, electrophysiology, and hypoxic conditions.

Available projects

The Nissen group currently has projects available for Master and PhD students. Please contact Group Leader Poul Nissen directly, if interested.

A collection of P-type ATPase structures from the Nissen lab. Figure courtesy of Dr. Oleg Sitsel.

News

FOTO: DANDRITE

2017.05.10 | Awards

DANDRITE receives a 5-year prolongation grant of DKK 60 million from Lundbeckfonden

The grant extends an ambitious neuroscience research initiative in Denmark and provides the DANDRITE researchers at Aarhus University with the opportunity to continue their work up until 2023. The aim is for groundbreaking, new studies of basic mechanisms in neuroscience such as in neuronal development, the processing of visual input, brain-muscle…

2017.05.05 | Awards

DANDRITE researchers receive DFF-Research Project Grants from the Danish Council for Independent Research

Core group leaders Anders Nykjær and Poul Nissen, group leader Sadegh Nabavi and team leader Magnus Kjærgaard are all recipients of research grants from the FNU, FSS and FTP sections of DFF.

Photo: PhD student Milena Laban (left)

2017.05.02 | Events

DANDRITE attended this year's Festival of Research in Aarhus on April 27

As usual DANDRITE attended the Festival of Research. It was a busy and enjoyable day where group leaders and students from DANDRITE demonstrated their research areas to the general Danish public. Four labs where represented: Anne von Philipsborn lab, Poul Henning Jensen lab, Mark Denham lab and Poul Nissen Lab.

Professor Poul Nissen. Photo: Novo Nordisk Foundation, Denmark
Professor Poul Nissen. Photo: AU Foto, Denmark
Professor Emmanuelle Charpentier. Photo: Hallbauer & Fioretti

2017.03.16 | Awards

Novo Nordisk Foundation Awards for professors at two Nordic EMBL partnership nodes

Two leading scientists from two Nordic EMBL Partnership sites, DANDRITE (Danish Research Institute of Translational Neuroscience) and MIMS (The Laboratory for Molecular Infection Medicine Sweden), have been awarded prestigious prizes from the Novo Nordisk Foundation.

The director of the Novo Nordisk Foundation Birgitte Nauntofte FOTO: AU Foto
Rector of Aarhus University Brian Bech Nielsen FOTO: AU Foto
FOTO: AU Foto
The Chairman of the Novo Nordisk Prize committee Jan Fahrenkrug FOTO: AU Foto
Professor Poul Nissen FOTO: AU Foto

2017.03.13 | Awards

Celebrating Poul Nissen - the Novo Nordisk Prize 2017 receiver

Professor Poul Nissen has been awarded the 2017 Novo Nordisk Prize. On that occasion, he gave a prize lecture on Friday March 10th followed by a reception hosted by the Novo Nordisk Foundation, both events set in the beautiful Lakeside Lecture Theatre. Birgitte Nauntofte, the director of the Novo Nordisk Foundation, and Brian Bech Nielsen, the…

2017.03.09 | Awards

Poul Nissen receives the Novo Nordisk Prize 2017

Poul Nissen, Professor at Aarhus University, is receiving the 2017 Novo Nordisk Prize for his pioneering studies of the structure and function of ion pumps. Through his research, Poul Nissen has clarified in detail, among other things, how ions and nutrients are transported into and out of cells. This fundamental knowledge is very significant for…

2016.12.13 | Awards

Poul Nissen received the Order of Dannebrog

At an audience Monday the 12th of December, Professor Poul Nissen had the opportunity to thank the queen for receiving the order of Dannebrog. The audience was held at Amalienborg Castle in Copenhagen. The order was given by her Majesty the Queen of Denmark earlier this year.

2016.11.23 | Awards

Poul Nissen awarded the Research Prize from Director Ib Henriksen Foundation

Poul Nissen has been awarded the prestigious Director Ib Henriksen Foundation Research Prize for his outstanding efforts in structural biology. In the center PUMPkin he has determined the structure of a number of essential ion pumps. The importance of these pumps in the heart and in neurological diseases has also been central to Poul Nissen's…

2016.08.09 | Research news

New publication from Poul Nissen's group - Engineering a Prototypic P-type ATPase Listeria monocytogenes Ca2+-ATPase 1 for Single-Molecule FRET Studies

Approximately 30% of the ATP generated in the living cell is utilized by P-type ATPase primary active transporters to generate and maintain electrochemical gradients across biological membranes. P-type ATPases undergo large conformational changes during their functional cycle to couple ATP hydrolysis in the cytoplasmic domains to ion transport…

2016.07.07 | People

Poul Nissen elected for EMBL's Scientific Advisory Committee

Prof. Poul Nissen, core group leader and director of DANDRITE, has been elected as a member of the EMBL's Scientific Advisory Committee (SAC), which is EMBL's chief advisory body on scientific matters. Poul Nissen has been elected for a three-year term starting from 1 January 2017.

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