Nykjær Group

Nykjær Group - Receptor Biology


Using transgenic animal models the Nykjær group is studying sortilin receptors in memory, trans-synaptic communication and signaling.

Research focus

Research activities are focused towards the functional characterization of a family of neuronal type-1 receptors denoted sortilins, comprising sortilin, SorLA, and SorCS-1, -2, and -3 with particular emphasis on their role in memory formation and recall, and in emotional regulation. Sortilins bind a vast number of ligands including neurotrophic factors, synaptic proteins, Alzheimer precursor protein (APP), and progranulin implying critical roles in regulation of neuronal survival, differentiation and integrity, and in synaptic plasticity. Indeed, a number of genetic association studies and gene targeting in mice have linked dysfunction of the sortilin receptors with neuropsychiatric and degenerative diseases including ADHD, schizophrenia, bipolar disorder, Alzheimer’s Disease, and frontotemporal lobar dementia.

Using transgenic mouse models, a broad repertoire of molecular, cellular and genetic tools, electrophysiology, mouse behavior, and confocal and two-photon microscopy it is our goal to unravel the function of the receptor family in health and disease and to evaluate their potential as drug targets.  

Available projects

The Nykjær group currently has projects available for Master students and postdocs within the following research areas.

Functions of the sortilin receptor family in health and disease:

  • Synaptic plasticity, memory, and psychiatric disorders
  • Functionality of the dopaminergic system

Please contact Group Leader Anders Nykjær directly, if interested.

News

2017.05.10 | Knowledge exchange

Anders Nykjær interviewed for DR Science

On Neuroscience Day 2017, Group Leader Anders Nykjær was interviewed for two articles by DR Science.

2017.05.05 | Awards

DANDRITE researchers receive DFF-Research Project Grants from the Danish Council for Independent Research

Core group leaders Anders Nykjær and Poul Nissen, group leader Sadegh Nabavi and team leader Magnus Kjærgaard are all recipients of research grants from the FNU, FSS and FTP sections of DFF.

Prof. Anders Nykjær

2017.04.19 | Research news

Prof. Anders Nykjær receives DKK 62 million granted to new basic research centre

Professor Anders Nykjær and DANDRITE colleagues have received the grant from the Danish National Research Foundation. The goal is to understand how emotional impressions affect our long-term memory.

2016.11.30 | Research news

Two grants awarded to Anders Nykjaer

Anders Nykjaer was granted DKK 750.000 by the Novo Nordisk Foundation for the project entitled “SorCS1 – boosting energy expenditure in obesity”. He also received a grant from the Danish Multiple Sclerosis Association (Scleroseforeningen) for the project entitled: ”Functional characterisation of the multiple sclerosis risk gene SORCS3."

2016.07.26 | Research news

New publication from Anders Nykjær's group - SorCS2 is required for BDNF-dependent plasticity in the hippocampus

SorCS2 is a member of the Vps10p-domain receptor gene family receptors with critical roles in the control of neuronal viability and function. Several genetic studies have suggested SORCS2 to confer risk of bipolar disorder, schizophrenia and attention deficit-hyperactivity disorder. Here we report that hippocampal N-methyl-d-aspartate…

2016.07.08 | Research news

New publication from Anders Nykjær's group - The proneurotrophin receptor sortilin is required for Mycobacterium tuberculosis control by macrophages

Sorting of luminal and membrane proteins into phagosomes is critical for the immune function of this organelle. However, little is known about the mechanisms that contribute to the spatiotemporal regulation of this process. Here, we investigated the role of the proneurotrophin receptor sortilin during phagosome maturation and mycobacterial…

2016.03.30 | Research news

New publication from Anders Nykjær's group - Sortilin mediates vascular calcification via its recruitment into extracellular vesicles

Vascular calcification is a common feature of major cardiovascular diseases. Extracellular vesicles participate in the formation of microcalcifications that are implicated in atherosclerotic plaque rupture; however, the mechanisms that regulate formation of calcifying extracellular vesicles remain obscure. Here, we have demonstrated that sortilin…

2014.12.01 | People

Anders Nykjær's group is visited by researchers from the Mayo Clinic Florida

PhD-student Maarten Rotman and Lab Manager Gangadaar Thotakura, Mayo Clinic Florida, will be visiting Anders Nykjær’s Group the first week of December. They both work in Anders Nykjær’s lab at Mayo Clinic and the purpose of their visit is to facilitate technology transfer in translational neuroscience between laboratories in Denmark and Florida.…

2014.11.17 | Research news

New publication from Anders Nykjær's group published in the Journal of Clinical Investigations

In this study "Targeting sortilin in immune cells reduces proinflammatory cytokines and atherosclerosis", the researchers identify a new mechanism critically involved in the development of ischemic heart disease. They report that sortilin, a multifunctional receptor enriched in neurons, has a surprising role outside the nervous system by…

2014.10.09 | People

Anders Nykjær is new professor at the Mayo Clinic

On October 1st 2014, Anders Nykjær was appointed Professor of Neuroscience at Mayo Medical School, Mayo Clinic Florida, where he has his own research laboratory. He will study the role of sortilin and its related receptors in neurodegenerative disorders. This appointment is in addition to his current professorship at Aarhus University, and he will…

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