Nykjær Group

Nykjær Group - Receptor Biology


Using transgenic animal models the Nykjær group is studying sortilin receptors in cellular sorting/trafficking, trans-synaptic communication, and neuronal development and signaling.

Research focus

Research activities are focused towards the functional characterization of a family of neuronal type-1 receptors denoted sortilins, comprising sortilin, SorLA, and SorCS-1, -2, and -3. Although expression predominates in neurons, receptors are also present in specialized cell types outside the nervous system. They bind a vast number of ligands spanning from neurotrophic factors, Alzheimer precursor protein (APP), and progranulin to lipoproteins, implying critical roles in regulation of neuronal survival, differentiation, and cholesterol metabolism. Indeed, a number of genetic association studies and gene targeting in mice have linked sortilin dysfunction with neurodegenerative disorders, ADHD, schizophrenia, bipolar disorder, hypercholesterolemia and diabetes.

Using transgenic mouse models and a broad repertoire of molecular, cellular and genetic tools it is the goal to unravel the function of the receptor family in health and disease and to evaluate their potential as drug targets.

Available projects

The Nykjær group currently has projects available for Master students and postdocs within the following research areas.

Functions of the sortilin receptor family in health and disease:

Signaling by neurotrophic factors
Synaptic plasticty and psychiatric disorders
Axonal development and ADHD
Neurodegeneration
Neuropathic pain
Functionality of the dopaminergic system
Olfactory system
Metabolism


Please contact Group Leader Anders Nykjær directly, if interested.

News

2018.02.13 | People

Jeppe Tranberg-Jensen is new bachelor student in Nykjær Group

Jeppe Tranbjerg-Jensen is a new bachelor student in Anders Nykjær group from February 1st. During the next 6 months, he will study axon outgrowth in primary motor neuron cultures and mice embryos to characterize the role of the receptor, SorCS2, in motor neuron development.

2018.02.08 | Awards

Anders Nykjær recieves DKK 15 mio. from the Lundbeck Foundation

Anders receives DKK 15 mio for the 5-year project "Sortilin - balancing synaptic strength and mood states".

2017.11.27 | People

Anne Kathrine Sørensen is new Research year student at Nykjær Group

Anne Kathrine Sørensen started as a research year student in Anders Nykjær’s group per 16 October 2017. For the next year, she will focus on the recently identified Multiple Sclerosis risk gene, SORCS3, studying the expression in the mouse brain, the connection to oligodendrocyte cell-linage, and the phenotype in KO mice. The aim is…

2017.09.05 | Research news

New publiction by team leader Arne Möller and colleagues

The title of the paper is: Hidden Twins: SorCS Neuroreceptors Form Stable Dimers

2017.08.01 | People

Mikhail Paveliev is new Postdoc in Nykjær Group

Mikhail is new Postdoc in Anders Nykjær's group per August 1st. He will study effects of the sortilin family members on brain synapses. In particular, Mikhail will focus on synaptic structure and molecular content by using advanced microscopy methods. The project aims at understanding the sortilin-related molecular mechanisms in pathology and…

2017.06.01 | Awards

Prof. Anders Nykjær receives DKK 250.000 from Foundation for Research in Neurology

Anders Nykjær receives DKK 250.000 for the project "Functional characterization of the multiple sclerosis risk gene SORCS3: a novel drug target".

2017.05.10 | Knowledge exchange

Anders Nykjær interviewed for DR Science

On Neuroscience Day 2017, Group Leader Anders Nykjær was interviewed for two articles by DR Science.

2017.05.05 | Awards

DANDRITE researchers receive DFF-Research Project Grants from the Danish Council for Independent Research

Core group leaders Anders Nykjær and Poul Nissen, group leader Sadegh Nabavi and team leader Magnus Kjærgaard are all recipients of research grants from the FNU, FSS and FTP sections of DFF.

Prof. Anders Nykjær

2017.04.19 | Research news

Prof. Anders Nykjær receives DKK 62 million granted to new basic research centre

Professor Anders Nykjær and DANDRITE colleagues have received the grant from the Danish National Research Foundation. The goal is to understand how emotional impressions affect our long-term memory.

2016.11.30 | Research news

Two grants awarded to Anders Nykjaer

Anders Nykjaer was granted DKK 750.000 by the Novo Nordisk Foundation for the project entitled “SorCS1 – boosting energy expenditure in obesity”. He also received a grant from the Danish Multiple Sclerosis Association (Scleroseforeningen) for the project entitled: ”Functional characterisation of the multiple sclerosis risk gene SORCS3."

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