Nissen Group


Nissen group - Structural and Functional Studies of Membrane Transporters in Brain


The Nissen group investigates molecular mechanisms of membrane transport processes and biomembrane structure. Activities are mainly focused on protein crystallography, biochemistry, electrophysiology, and include also small-angle X-ray scattering and electron microscopy. Main subjects of research concern P-type ATPase (ion pumps and lipid flippases) and Na+ dependent transporters, but include also structure based drug discovery and protein engineering. 

Research focus


The main focus of our research is to investigate the membrane transporters involved with neurological and psychiatric disorders. The Na+, K+-ATPase is of particular interest, since many neurological disorders are linked to the function of this pump, such as function loss in the Na+,K+-ATPase that can lead to severe diseases such as familial hemiplegic migraine and rapid-onset Dystonia with Parkinsonism.

Several different methods are used to study membrane pumps in our research group, such as structural studies including use of nanodiscs, electrophysiology, and hypoxic conditions.

Available projects

The Nissen group currently has projects available for Master and PhD students. Please contact Group Leader Poul Nissen directly, if interested.

A collection of P-type ATPase structures from the Nissen lab. Figure courtesy of Dr. Oleg Sitsel.

News

2013.12.08 | Research news

New publication - Copper-transporting P-type ATPases use a unique ion-release pathway

New publication from Poul Nissen's group published in the Journal Nature Structural & Molecular Biology. Results from this study provide deeper insight into causes of serious diseases involving copper metabolism. Mapping the mechanism that regulates the transport of copper across the cell membrane and out of the body’s cells actually provides a…

2013.09.30 | Research news

New publication - Heterologous expression and purification of an active human TRPV3 ion channel

New publication from Poul Nissen's group published in FEBS Journal. The transient receptor potential vanilloid 3 (TRPV3) cation channel is widely expressed in human tissues and has been shown to be activated by mild temperatures or chemical ligands. We demonstrate that the recombinant purified protein contains high ?-helical content and migrates…

2013.09.19 | Research news

New publication from Poul Nissen's group - Crucial new insight into the secrets of Nobel Prize-winning pump

Jens Chr. Skou was awarded the Nobel Prize for his discovery of the sodium-potassium pump. Now, a team of researchers from Aarhus has completed the description of its structure. A result which is of vital importance for our understanding of the body's functions and essential for our understanding of illness and for the development of new medicines.

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