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Nissen Group


Nissen group - Structural and Functional Studies of Membrane Proteins in Brain

 

The Nissen group investigates molecular mechanisms of membrane transport processes, receptors, and biomembrane ultrastructure. Activities are mainly focused on cryo-electron microscopy (Cryo-EM), protein crystallography, biochemistry, electrophysiology, and include also small-angle X-ray scattering and cryo-electron tomography. Main subjects of research concern membrane transporters and receptors involved with neurological and psychiatric disorders, i.e. P-type ATPase (Na,K-ATPase, Ca-ATPases, lipid flippases, P5-ATPases), Na+ dependent neurotransmitter and chloride transporters, and insulin receptor signaling. studies include also structure based drug discovery and protein engineering. Biomembrane ultrastructures of neurons focus on axons and synapses associated with memory.

Our investigations link also to translational studies of neurological and psychiatric disorders associated with perturbed ion transport or metabolic control. 

Methods development, integrative structural biology, and bioimaging are also of great interest to the group.

Research Areas: Membrane proteins, Membrane transport and signaling, single-particle Cryo-EM, Cryo-Electron Tomography, Crystallography, Biochemistry, Drug discover

A collection of P-type ATPase structures from the Nissen lab. Figure courtesy of Dr. Oleg Sitsel.

Available projects

The Nissen group currently has projects available for Master and PhD students.

See current research projects in the laboratory here (link opens pdf)

See overview of current study opportunities in the laboratory (link opens new page)

Please contact Group Leader Poul Nissen directly, if interested.

News

2018.02.06 | MarkDenham

New publication from Mark Denham's group in collaboration with Poul Nissen

The article is just published in Frontiers. Title: Central and Peripheral Nervous System Progenitors Derived from Human Pluripotent Stem Cells Reveal a Unique Temporal and Cell-Type Specific Expression of PMCAs.

2018.01.26 | Research news

Novo Nordisk Foundation awards DKK 255 million for establishing the world’s most powerful protein “microscope”

The Novo Nordisk Foundation is supporting the establishment of an ultra-modern research platform in Lund, Sweden. The platform will enable researchers to investigate proteins at a level of detail not previously possible and can thus form the basis for developing new drugs. Researchers from Aarhus University have had a strong impact on the…

2018.01.24 | Knowledge exchange

Nordic network in Nobel Prize–winning technology

A new Danish-Swedish research alliance wants to advance understanding of how biological molecules look and behave. With support from the Novo Nordisk Foundation and the Knut and Alice Wallenberg Foundation, scientists at four universities in Denmark and Sweden will join forces to create a Nordic network in cryo-electron microscopy, whose…

2018.01.17 | Awards

Sara Basse receives a PhD Fellowship from the Boehringer Ingelheim Fonds

The stipend will continue Sara's PhD studies with Magnus Kjærgaard and Poul Nissen. She will investigate the structural and mechanistic basis of unidirectional calcium transport through direct visualization by single-molecule FRET and FRET-guided crystallization of key intermediates, and she will establish techniques for…

2018.01.09 | People

Foteini Karapanagioti is visiting student in Poul Nissen's group

During her visit Foteini Karapanagioti will be investigating the effects of arrythmogenic calmodulin mutations on the regulation of cardiac plasma membrane Ca2+ ATPase. She is visiting master student from Aalborg University and will be visiting for ½ year.

2017.12.01 | Awards

Michael Voldsgaard Clausen and Poul Nissen has been granted DKK 400,000 to Research Infrastructure from the Carsberg Foundation

Project title: Feel the Force - How do cellular membranes couple force to electrical signaling

2017.11.30 | Awards

Prof. Poul Nissen receives DKK 132,000 from AUFF to host Assoc. Prof. Elizabeth Wright as a visiting professor in March and April 2018.

The visiting research grant will support new studies of neuronal membrane structures by Correlative Light and Electron Microscopy and Cryo-Electron Tomography.

(Photo: Mateusz Dyla)

2017.11.09 | PoulNissen

Poul Nissen, Mateusz Dyla and Magnus Kjærgaard publish article in the leading journal Nature

The article ‘Dynamics of P-type ATPase transport revealed by single-molecule FRET’ was published yesterday on 8 November 2017. Our cells are capable of moving energy and material around to the places where they are required, and ensuring that the body works properly. But how do the cells do this in real time from the perspective of the…

2017.11.02 | People

Esben Quistgaard is new assistant professor in Nissen Group

Esben Quistgaard is new assistant professor in Poul Nissen's group from November 3rd 2017. He comes from a position as a senior scientist at Karolinska Institutet in Stockholm where he has worked on structural characterization of membrane proteins using X-ray crystallography. He will now continue studying this class of proteins, but will shift…

2017.10.10 | Awards

Prestigious poster prizes to DANDRITEs at Conference in Otsu, Japan

At the 15th meeting on Na,K-ATPase and related P-type ATPases in Otsu, Japan three DANDRITE's received prestigious poster prizes. Joseph Lyons received the first prize and the second prizes went to Milena Laban and Michael Habeck.

2017.10.10 | People

Sofia Trampari is new PhD Student in Nissen Group

Sofia Trampari is new PhD Student in Nissen Group from October 1st. During her studies in Solid State and Condensed Matter Physics, Sofia had the opportunity to experience the fascinating world of Crystallography. Her innate passion to discover the world and the need to work towards finding ways to improve people’s wellbeing…

2017.10.09 | Research news

Poul Nissen interviewed for Videnskab.dk

Three chemists receive the Nobel Prize for making molecules visible. This year the development of a technique for creating biological molecules, Kryo-electron microscopy, is honored. Poul Nissen has worked with two of this years' three Nobel Prize winners in chemistry, Joachim Frank and Richard Henderson. Read interviews with Poul Nissen…

2017.09.01 | People

Samuel Hjorth-Jensen is new PhD student in Nissen Group

Samuel is a new PhD student in Poul Nissen’s group, starting as of September 1st. He will be studying proton pumping in the sarcoplasmic reticulum calcium ATPase (SERCA) using neutron diffraction techniques. The project aims to determine the mechanism of proton countertransport in SERCA by mapping the distribution of hydrogens along a…

2017.08.11 | People

Jeppe A. Nielsen is new PhD Student in Nissen lab

Jeppe is new PhD student in Nissen's group. About his PhD project Jeppe writes: "A model of the holo-insulin receptor (hIR) complex with insulin is “the holy grail” in the structural biology of insulin signaling. Atomic 3D models of hIR will provide insight into the determinants of insulin binding and recognition and depict the transmembrane…

2017.08.02 | People

Jonathan Juhl is new PhD Student in Nissen group

Jonathan took his bachelor in nanoscience giving him a profound insight into visualization of nanosized  biomolecules. Elucidating the structure and dynamics of biomolecules have interested Jonathan for many years which is why he became interested in the developing field, cryo-EM. His research is…

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