Study opportunities

Poul Henning Jensen's lab

Lab background:

The questions we address are how the protein alpha-synuclein is involved in the neurodegenerative diseases Parkinson’s disease, Lewy body dementia and multiple systems atrophy. We conduct studies in purified systems with recombinant alpha-synuclein, but also experiments in cells, brain cell cultures, and in gene modified mouse models. We focus on the mechanisms involved in the cellular dysfunctions caused by intracellular alpha-synuclein aggregation, how the process is spreading within the nervous system, and tissue responses of the brain to the processes. The aim is to identify mechanisms that can modulate the disease in patients. 

See more at the group website: www.dandrite.au.dk/jensen

Available projects:

Examples of current Ph.D. projects, evolved from master projects, are:

1) “The role of Polo-like kinase 2 in alpha-synuclein dependent neurodegeneration”

2) “Cellular calcium dysfunction in alpha-synuclein dependent neurodegeneration with a focus on mitochondria”

3) “Deubiquitinase USP-19’s role in cellular homeostasis during build-up of alpha-synuclein aggregates”.

Methods:

Biochemistry, molecular biology, cell biology, imaging, antibody based techniques, animal tissue and behavioral analyses.

The successful applicant is:

The Neurodegenerative Disease Laboratory is seeking enthusiastic student interested in conducting their master studies in the group. Students finding our topic or area of focus interesting are most welcome to contact us.

Other projects available:

We have more postdocs and phd projects wherein master projects can be conducted and with a high degree of supervision.

Please contact Group Leader Poul Henning Jensen directly, if interested