Jensen Group

Jensen Group - Neurodegenerative Disease Laboratory


Our group is interested in understanding how alpha-synuclein contributes to the neurodegenerative processes in Parkinson’s disease, Lewy body dementia and multiple systems atrophy, which are hallmarked by the development of intracellular aggregates of alpha-synuclein. This is investigated in studies of alpha-synuclein aggregates in vitro, in cell models, transgenic animals and human tissue and involves development of new aggregate selective tools.

Research focus


The aim is to decipher how cells regulate their pools of alpha-synuclein species and how they respond to misfolded alpha-synuclein with respect to cytotoxic and protective mechanisms that can be targeted by therapy. This involves proteostatic mechanisms like autophagy, unconventional secretion, prion-like intercellular propagation and homeostatic cellular mechanisms being offset by alpha-synuclein aggregates.

Currently specific projects focuses on alpha-synucleins role in calcium regulation, kinase pathways regulating alpha-synuclein turn-over and toxicity, relation to the innate immune system and implementation of a mouse model for prion-like spreading of alpha-synuclein brain pathology.

Available projects


The Jensen group currently has projects available for Master and PhD students. Please contact Group Leader Poul Henning Jensen directly, if interested.

News

2013.12.17 | Research news

New publication - Prodegenerative IkBalpha expression in oligodendroglial alpha-synuclein models of multiple system atrophy

New publication from Poul Henning Jensen's group published in Journal of Neurobiology of Disease. Multiple system atrophy (MSA) is a progressive, neurodegenerative disease characterized by parkinsonism, ataxia, autonomic dysfunction, and accumulation of alpha-synuclein in oligodendrocytes. Favoring oligodendroglial NF-kB activation may represent a…

2013.12.11 | Research news

New publication - Characterizing the dynamics of alpha-synuclein oligomers using hydrogen/deuterium exchange monitored by mass spectrometry

New publication from Poul Henning Jensen's group published in Journal of Biochemistry. Soluble oligomers formed by alpha-synuclein (alphaSN) are suspected to play a central role in neuronal cell death during Parkinson's disease. In this study, the structural dynamics of soluble alphaSN oligomers was analyzed using hydrogen/deuterium exchange…

2013.10.10 | Research news

New publication from Poul Henning Jensen's group - Structural and functional characterization of two alpha-synuclein strains

New results published in Nature Communications on the structure and function of two polymorphs of alpha-synuclein, a protein implicated in a number of neurological diseases such as for example Parkinson and dementia.

Showing results 11 to 13 of 13

Previous 1 2