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Morten Schallburg Nielsen

Transport across the Blood Brain Barrier


Research Focus

Our primary focus is receptor-mediated transport systems in brain endothelial cells, which have the potential to mediate transcytosis of nanocarriers across the Blood-Brain Barrier (BBB). Though, previous studies using the transferrin receptor and LRP1 have succeeded in transporting drugs across the endothelium, the mechanisms are far from understood. In our group we will characterize different subcellular trafficking routes of known and novel receptors in brain endothelial cells, in order to find the optimal receptor systems for drug delivery to the brain.

Methods

Our studies are primarily based on state-of-the-arte imaging system such as confocal, spinning disk, high content screening and TIRF in combination with in vitro BBB models using primary cells from mouse and pig brain.      

Additional techniques applied in the laboratory includes cell culture, transient and stable knockdown, protein/RNA/DNA biochemistry, molecular cloning, radioimmuno-based assays, subcellular fractionation, co-immunoprecipitation, antibody production and purification, Next Generation Sequencing, luciferase validation, qPCR and more.

Available projects

Our work includes a detailed classification of the endo-lysosomal system and functional internalization mechanisms in in vitro models of the BBB, testing particle penetrance across the BBB of modified nanoparticles and advancement of flourescence techniques.

News

2019.02.18 | MortenSchallburg Nielsen

Welcome to new Postdoc Diana Hudecz

Diana Hudecz joined Morten Schallburg Nielsen’s group as a postdoctoral fellow in February 2019, where she will work with receptors in brain endothelial. One of the aims of her research is to investigate the receptor expression in the entire brain using animal models and light sheet fluorescence microscopy. Furthermore, she will study the…

2019.02.13 | Research news

Danish researchers aim at finding ways through the brain's defense mechanisms

The news article is currently only available in Danish. Forskere fra Aarhus Universitet og Københavns Universitet tager del i et stort europæisk forskningskonsortium, som har til formål at finde nye måder at behandle hjernelidelser på. Konsortiet er finansieret af en bevilling på 67 mio. kr. fra EU’s Innovative Medicines Initiative.

2017.11.06 | Research news

DKK 300,000 to research into improved medication of patients with Alzheimer’s and Parkinson’s disease

Associate Professor and PhD Morten Schallburg Nielsen from the Department of Biomedicine at Aarhus University is receiving DKK 300,000 from the Riisfort Foundation. The grant will go towards funding research into the blood-brain barrier, and lead to the improved medication of patients with Alzheimer’s and Parkinson’s disease.

2017.09.21 | People

Morten Schallburg Nielsen is new affiliated researcher at DANDRITE

Associate professor Morten Schallburg Nielsen is new affiliated researcher in DANDRITE from September 2017. His primary focus is receptor-mediated transport systems in brain endothelial cells, which have the potential to mediate transcytosis of nanocarriers across the Blood-Brain Barrier (BBB). Though, previous studies using the…