Marco Capogna

Amygdala-hippocampal-cortical circuits in health and disease

The overarching aim of the research activities is to define the neuronal circuits of the human and rodent cerebral cortex and connected subcortical areas, as they are cellular regulators of cognitive process in health and disease. We wish to define what neuronal circuitry guides emotional-dependent learning and memory, and how it is modified in animal models of fear and anxiety disorders.

To achieve this goal we investigate the structure and the function of various neuron types in the rodent amygdala, hippocampus and prefrontal cortex. Major focus is on GABAergic neuron types because of their critical role in controlling circuits activity and because of their diversity. We also investigate the structure, function, communication and responses to drugs of neurons in the human cerebral cortex, the largest and most frequently affected brain area in disease.

My research group uses an integrated approach combining electrophysiology, neuropharmacology, optogenetic, cellular imaging and high resolution anatomy. Understanding the neural mechanisms controlling cortex-hippocampal-amygdala network activity may eventually lead to novel therapeutic strategies to reverse or ameliorate psychiatric disorders.

Neurogliaform cell in the rodent hippocampus.

Neurogliaform cell in the rodent hippocampus: (a) Unitary inhibitory postsynaptic current (IPSC) recorded in a neurogliaform neuron (lower traces) and evoked by activation of a presynaptic neurogliaform cell (upper trace).(b) Left: reconstruction of a neurogliaform cell (soma and dendrites, red; axon, green) and postsynaptic pyramidal cell (black) of the hippocampus. Right: voltage-clamp recording between the neurogliaform cell and the CA1 pyramidal cell pair shown on the left. Presynaptic action current evokes slow IPSC blocked by gabazine.(c) Left: reconstruction of a neurogliaform cell in the stratum lacunosum area CA1 of hippocampus (soma and dendrites, red; axon, green). Right: firing patterns of an identified hippocampal neurogliaform cell (bottom trace) during spontaneous network oscillations (upper three traces).Theta phase firing probability histogram showing phase-locking of the firing to two theya cycles.

Video: Shedding light on Hippocampus-amygdala communication

Video: THX-31 Large intercalated neuron rat amygdala - Neurolucidal reconstruction


2018.01.26 | People

Wen-Hsien Hou is new postdoc in Capogna Group

Wen-Hsien Hou is a new postdoc in Marco Capogna's group supported by AUFF NOVA from January 15th.

2018.01.26 | People

Meet Jariwala is new PhD student in Capogna Group

Meet Jariwala is new PhD student in Marco Capogna's group supported by PROMEMO from January 1st.

2017.12.04 | Events

Graduate Course: Understanding the Brain through the Hippocampus and other neural systems 2017 organized by Marco Capogna

The four day course (28 November-1 December 2017), held at Aarhus University, has addressed key topics in molecular, cellular and system neuroscience. The vision from which the course is based is that explanation of normal and pathological events in the brain can only come from the rigorous definition of the neuronal circuits that underlie these…

2017.11.08 | Awards

Marco Capogna granted DKK 500.000 by Lundbeckfonden

The money is granted to investigate neuron types of hippocampal-amygdala networks in rodents.

2017.10.02 | People

Emma Louth is new postdoc in Capogna Group

Emma Louth is new postdoc in Marco Capogna's group from October 1st. She will be investigating neuronal circuits in human cortical tissue. Using a combination of electrophysiological, neuropharmacological and imaging techniques she will characterize neurons in human cortical samples, elucidate dis-inhibitory circuitry and identify…

2017.05.17 | Research news

Marco Capogna and Sadegh Nabavi publish a paper in the prestigious journal Neuron edited by Cell Press, 17 May 2017

The title of the paper is: “Synaptic plasticity and network oscillations in amygdala circuits for storage and retrieval of emotional memories”.

Figure legend: A) Biocytin-filled principal neuron of the basal amygdala showing a sparse axon with long-projecting branches (left) and spiny dendrites (right). B) Top: example electrophysiological recording of principal neuron spiking. Optical stimulation for 30 s at 20 Hz of 5-HT axons reduced the neuron firing rate. Bottom: Quantification of pooled data. Upper blue stimulation bar denotes optogenetic stimulation.

2017.02.17 | Research news

New publication from Marco Capogna in The Journal of Neuroscience

The article is titled "Control of amygdala circuits by 5-HT neurons via 5-HT and glutamate co-transmission". The autors are Ayesha Sengupta, Marco Bocchio, David M. Bannerman, Trevor Sharp & Marco Capogna.

2016.12.08 | Research news

Marco Capogna and Peter Somogyi collaborate in new project funded by ERC Avanced Grant

Marco Capogna will collaborate with Peter Somogyi (Brain Prize winner 2011) in a project funded by an ERC Advanced Grant awarded from 1 December 2016 for 5 years.

2016.10.26 | People

Marco Capogna is now Affiliated Researcher in DANDRITE

Marco Capogna is Affiliated Researcher in DANDRITE with Sadegh Nabavis and Duda Kvitsianis group. He will be working with amygdala-hippocampal-cortical circuits in health and disease.