Christian Vægter

PNS neuron-glia interactions in health and disease - implications in Pain and Regenerative Processes 


The peripheral sensory neurons are completely covered by glial cells, with satellite glial cells (SCG) covering the neuronal soma and Schwann cells covering the length of the axon. It is therefore obvious that these glia cells play major roles in how the neurons function, and that diseases affecting the glia have dramatic consequences for the functionality of the neurons. 

Our aim is to understand how peripheral glia cells affect neuronal functionality in health but also following nerve injury or in diseases such as diabetes. Our research span from molecular biology, cells lines and primary cultures, tissue analysis with confocal microscopy to experiments with mice and rats (microsurgery and behavioral analysis).  


Available projects

There are currently projects available for Bachelor, Master, PhD and research year students in the group. Please contact Christian Vægter directly for more information, if interested.

Topics include (but are not limited to): 

  • SGC response after nerve injury (on transcriptional and protein levels) 
  • Spinal cord plasticity in pain processes
  • Microglia and pain
  • Schwann cell communication by exosomes in diabetes
  • The sortilins and injury responses

 

Left: Electron microscopy image of mouse sciatic nerve visualizing unmyelinated sensory neuron axons (Remak bundle) and myelinated axons. Right: Sensory neurons from mouse dorsal root ganglia (DRG) grown in culture. (figures: Christian Vægter)