2013.12.17 | Research news

New publication - Prodegenerative IkBalpha expression in oligodendroglial alpha-synuclein models of multiple system atrophy

New publication from Poul Henning Jensen's group published in Journal of Neurobiology of Disease. Multiple system atrophy (MSA) is a progressive, neurodegenerative disease characterized by parkinsonism, ataxia, autonomic dysfunction, and accumulation of alpha-synuclein in oligodendrocytes. Favoring oligodendroglial NF-kB activation may represent a…

2013.12.11 | Research news

New publication - Characterizing the dynamics of alpha-synuclein oligomers using hydrogen/deuterium exchange monitored by mass spectrometry

New publication from Poul Henning Jensen's group published in Journal of Biochemistry. Soluble oligomers formed by alpha-synuclein (alphaSN) are suspected to play a central role in neuronal cell death during Parkinson's disease. In this study, the structural dynamics of soluble alphaSN oligomers was analyzed using hydrogen/deuterium exchange…

2013.12.08 | Research news

New publication - Copper-transporting P-type ATPases use a unique ion-release pathway

New publication from Poul Nissen's group published in the Journal Nature Structural & Molecular Biology. Results from this study provide deeper insight into causes of serious diseases involving copper metabolism. Mapping the mechanism that regulates the transport of copper across the cell membrane and out of the body’s cells actually provides a…