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Nissen Group


Nissen group - Structural and Functional Studies of Membrane Proteins in Brain

 

The Nissen group investigates molecular mechanisms of membrane transport processes, receptors, and biomembrane ultrastructure. Activities are mainly focused on cryo-electron microscopy (Cryo-EM), protein crystallography, biochemistry, electrophysiology, and include also small-angle X-ray scattering and cryo-electron tomography. Main subjects of research concern membrane transporters and receptors involved with neurological and psychiatric disorders, i.e. P-type ATPase (Na,K-ATPase, Ca-ATPases, lipid flippases, P5-ATPases), Na+ dependent neurotransmitter and chloride transporters, and insulin receptor signaling. studies include also structure based drug discovery and protein engineering. Biomembrane ultrastructures of neurons focus on axons and synapses associated with memory.

Our investigations link also to translational studies of neurological and psychiatric disorders associated with perturbed ion transport or metabolic control. 

Methods development, integrative structural biology, and bioimaging are also of great interest to the group.

Research Areas: Membrane proteins, Membrane transport and signaling, single-particle Cryo-EM, Cryo-Electron Tomography, Crystallography, Biochemistry, Drug discover

A collection of P-type ATPase structures from the Nissen lab. Figure courtesy of Dr. Oleg Sitsel.

Available projects

The Nissen group currently has projects available for Master and PhD students.

See current research projects in the laboratory here (link opens pdf)

See overview of current study opportunities in the laboratory (link opens new page)

Please contact Group Leader Poul Nissen directly, if interested.

News

2017.10.10 | People

Sofia Trampari is new PhD Student in Nissen Group

Sofia Trampari is new PhD Student in Nissen Group from October 1st. During her studies in Solid State and Condensed Matter Physics, Sofia had the opportunity to experience the fascinating world of Crystallography. Her innate passion to discover the world and the need to work towards finding ways to improve people’s wellbeing…

2017.10.09 | Research news

Poul Nissen interviewed for Videnskab.dk

Three chemists receive the Nobel Prize for making molecules visible. This year the development of a technique for creating biological molecules, Kryo-electron microscopy, is honored. Poul Nissen has worked with two of this years' three Nobel Prize winners in chemistry, Joachim Frank and Richard Henderson. Read interviews with Poul Nissen…

2017.09.01 | People

Samuel Hjorth-Jensen is new PhD student in Nissen Group

Samuel is a new PhD student in Poul Nissen’s group, starting as of September 1st. He will be studying proton pumping in the sarcoplasmic reticulum calcium ATPase (SERCA) using neutron diffraction techniques. The project aims to determine the mechanism of proton countertransport in SERCA by mapping the distribution of hydrogens along a…

2017.08.11 | People

Jeppe A. Nielsen is new PhD Student in Nissen lab

Jeppe is new PhD student in Nissen's group. About his PhD project Jeppe writes: "A model of the holo-insulin receptor (hIR) complex with insulin is “the holy grail” in the structural biology of insulin signaling. Atomic 3D models of hIR will provide insight into the determinants of insulin binding and recognition and depict the transmembrane…

2017.08.02 | People

Jonathan Juhl is new PhD Student in Nissen group

Jonathan took his bachelor in nanoscience giving him a profound insight into visualization of nanosized  biomolecules. Elucidating the structure and dynamics of biomolecules have interested Jonathan for many years which is why he became interested in the developing field, cryo-EM. His research is…

2017.06.01 | People

Michael Habeck is new Postdoc in Nissen Group

Michael is interested in structural studies of Na,K-ATPase isoforms and mutations causing neurological diseases.

FOTO: DANDRITE

2017.05.10 | Awards

DANDRITE receives a 5-year prolongation grant of DKK 60 million from Lundbeckfonden

The grant extends an ambitious neuroscience research initiative in Denmark and provides the DANDRITE researchers at Aarhus University with the opportunity to continue their work up until 2023. The aim is for groundbreaking, new studies of basic mechanisms in neuroscience such as in neuronal development, the processing of visual input, brain-muscle…

2017.05.05 | Awards

DANDRITE researchers receive DFF-Research Project Grants from the Danish Council for Independent Research

Core group leaders Anders Nykjær and Poul Nissen, group leader Sadegh Nabavi and team leader Magnus Kjærgaard are all recipients of research grants from the FNU, FSS and FTP sections of DFF.

2017.05.05 | People

Thomas Lykke-Møller Sørensen is Visiting Researcher in Nissen Group

Thomas is a Visiting Researcher in Poul's group from May 1st. Thomas is Principal Beamline Scientist (VMXi beamline) at the Diamond Light Source (www.diamond.ac.uk) and visiting professor at University of Portsmouth, UK. Thomas is visiting the Nissen group for the next 6 months to study the proton translocation pathway within SERCA by developing…

Photo: PhD student Milena Laban (left)

2017.05.02 | Events

DANDRITE attended this year's Festival of Research in Aarhus on April 27

As usual DANDRITE attended the Festival of Research. It was a busy and enjoyable day where group leaders and students from DANDRITE demonstrated their research areas to the general Danish public. Four labs where represented: Anne von Philipsborn lab, Poul Henning Jensen lab, Mark Denham lab and Poul Nissen Lab.

Professor Poul Nissen. Photo: Novo Nordisk Foundation, Denmark
Professor Poul Nissen. Photo: AU Foto, Denmark
Professor Emmanuelle Charpentier. Photo: Hallbauer & Fioretti

2017.03.16 | Awards

Novo Nordisk Foundation Awards for professors at two Nordic EMBL partnership nodes

Two leading scientists from two Nordic EMBL Partnership sites, DANDRITE (Danish Research Institute of Translational Neuroscience) and MIMS (The Laboratory for Molecular Infection Medicine Sweden), have been awarded prestigious prizes from the Novo Nordisk Foundation.

The director of the Novo Nordisk Foundation Birgitte Nauntofte FOTO: AU Foto
Rector of Aarhus University Brian Bech Nielsen FOTO: AU Foto
FOTO: AU Foto
The Chairman of the Novo Nordisk Prize committee Jan Fahrenkrug FOTO: AU Foto
Professor Poul Nissen FOTO: AU Foto

2017.03.13 | Awards

Celebrating Poul Nissen - the Novo Nordisk Prize 2017 receiver

Professor Poul Nissen has been awarded the 2017 Novo Nordisk Prize. On that occasion, he gave a prize lecture on Friday March 10th followed by a reception hosted by the Novo Nordisk Foundation, both events set in the beautiful Lakeside Lecture Theatre. Birgitte Nauntofte, the director of the Novo Nordisk Foundation, and Brian Bech Nielsen, the…

2017.03.09 | Awards

Poul Nissen receives the Novo Nordisk Prize 2017

Poul Nissen, Professor at Aarhus University, is receiving the 2017 Novo Nordisk Prize for his pioneering studies of the structure and function of ion pumps. Through his research, Poul Nissen has clarified in detail, among other things, how ions and nutrients are transported into and out of cells. This fundamental knowledge is very significant for…

2016.12.13 | Awards

Poul Nissen received the Order of Dannebrog

At an audience Monday the 12th of December, Professor Poul Nissen had the opportunity to thank the queen for receiving the order of Dannebrog. The audience was held at Amalienborg Castle in Copenhagen. The order was given by her Majesty the Queen of Denmark earlier this year.

2016.11.23 | Awards

Poul Nissen awarded the Research Prize from Director Ib Henriksen Foundation

Poul Nissen has been awarded the prestigious Director Ib Henriksen Foundation Research Prize for his outstanding efforts in structural biology. In the center PUMPkin he has determined the structure of a number of essential ion pumps. The importance of these pumps in the heart and in neurological diseases has also been central to Poul Nissen's…

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