Jensen Group

Jensen Group - Neurodegenerative Disease Laboratory


Our group is interested in understanding how alpha-synuclein contributes to the neurodegenerative processes in Parkinson’s disease, Lewy body dementia and multiple systems atrophy, which are hallmarked by the development of intracellular aggregates of alpha-synuclein. This is investigated in studies of alpha-synuclein aggregates in vitro, in cell models, transgenic animals and human tissue and involves development of new aggregate selective tools.

Research focus


The aim is to decipher how cells regulate their pools of alpha-synuclein species and how they respond to misfolded alpha-synuclein with respect to cytotoxic and protective mechanisms that can be targeted by therapy. This involves proteostatic mechanisms like autophagy, unconventional secretion, prion-like intercellular propagation and homeostatic cellular mechanisms being offset by alpha-synuclein aggregates.

Currently specific projects focuses on alpha-synucleins role in calcium regulation, kinase pathways regulating alpha-synuclein turn-over and toxicity, relation to the innate immune system and implementation of a mouse model for prion-like spreading of alpha-synuclein brain pathology.

Available projects


The Jensen group currently has projects available for Master and PhD students. Please contact Group Leader Poul Henning Jensen directly, if interested.

News

2018.11.05 | PoulHenningJensen

Lixiang Jiang is a new PhD student in Jensen Group.

As a new PhD student in Jensen Group, Lixiang Jiang, will be working on a project Regulation of α-synuclein transcription by the PLK-2/GSK-3β signalling pathway – a potential modulator of Parkinson’s disease risk.

Alexander Asferg

2018.10.31 | PoulHenningJensen

Alexander Asferg is new student in Jensen Group

Alexander is a Bachelor student in Molecular Biology and has joined the Jensen Group for his bachelors project. He is currently working with the AIAS Fellow Asad Jan, who is developing suitable genome editing tools to block the prion-like spread of alpha-synuclein in vivo.  Alexander is assisting in the preliminary work on this project.

2018.10.30 | PoulHenningJensen

Jensen Group receives 350,000 DKK from Parkinsonforeningen (The Parkinson's Foundation)

The grant is assigned to "investigate whether attempts to increase neurons cytosolic calcium levels protect a mouse model of progressive Parkinson’s disease – Effects of SERCA inhibition and activation of calcium channels."

2018.09.05 | PoulHenningJensen

Hjalte Gram is new Research Assistant in Poul Henning Jensens' group

Hjalte Gram is employed in Poul-Henning Jensens group as research assistant per 1'st of august 2018. He will work on factors leading to pathological aggregation of a central protein in Parkinson’s disease, a-synuclein, using animal and cell studies.'

2018.07.03 | People

Marie Vestergaard is new Bachelor Student in Jensen Group

Marie Vestergaard is new Bachelor Student in Jensen Group. She will be working with immunohistochemistry and Proximity Ligation assay on different types of tissues.

2018.07.02 | People

Andreas Baun is new Bachelor Student in Jensen group

Andreas Baun is new Bachelor Student in Jensen Group. He will work on a project comparing alpha-synuclein aggregates generated under different conditions biochemically and also analyze differences in toxicity on cells.

2018.05.01 | People

Golshah Ayoubi is new Laboratory Technician in Jensen Group

Golshah is new Laboratory Technician in Poul Henning Jensen's Group from 23rd of April. Please give her a warm welcome.

2018.02.05 | PoulHenningJensen

Nanna Møller Jensen is new master student in Jensen Group

Nanna is a Master student in Molecular Medicine and will be part of Poul Henning's research group for the next 1,5 years. Here, she will primarily be working with organotypic brain slices as an in vitro model for Parkinson's disease in order to investigate the characteristics of alpha synuclein spreading.

2018.01.15 | People

Nelson Ferreira has been prolonged for 1 year as postdoc in Jensen Group

Nelson Ferreira will be responsible for overseeing the mouse colonies in Poul Henning Jensen’s group apart from continuing his current postdoctoral research on in vivo prion-like spreading of α-synuclein dependent neuropathology and the molecular basis for development of strains associated to different α-synucleinopathies.

2018.01.08 | Awards

Poul Henning Jensen receives DKK 3,8 millions from The Michael J. Fox Foundation

Poul Henning receives the grant for his research on Parkinson's disease. Please read the entire news story here (only in Danish).

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