Denham Group

Denham group - Stem Cells


The Denham group is working with human embryonic stem cells and induced pluripotent stem cells to study how the nervous system develops and the processes involved in neurodegeneration. In particular, he is interested in the specification of mesencephalic dopaminergic neurons, the major cell type affected in Parkinson’s disease. He has developed efficient protocols for generating mesencephalic dopaminergic neurons and uncovered some of the key molecular mechanisms that underlie this process.

Research focus


The main focus of our research is to investigate the signalling pathways required for the specification of precise neural cell types from the pluripotent state, from which our objectives are to use these derivatives to develop in vitro models for studying neurodegenerative diseases. Using this approach our aims are to identify early cellular changes that underlie the onset of neurodegeneration for diseases such as Parkinson’s disease.

Furthermore, we are also interested in how different neural progenitor subtypes survive and function after transplantation in an adult rodent brain. Our overall goals are to develop potential treatment strategies for neurodegenerative disorders in the form of cell replacement therapies and drug development.


Projects for Master and ERASMUS students currently available

If interested, please contact Group Leader Mark Denham directly (mden@biomed.au.dk) for further information. See further information on projects here

Human pluripotent stem cell derived neurosphere differentiated into neurons in vitro using a small molecule induction system (Denham et al., Stem Cells, 2012).

News

Mark Denham

2018.11.29 | People

Congratulations to Mark Denham, who has had his Group Leader extension approved

The Executive Board of DANDRITE has approved the recommendations from the Assessment Committee to extend Mark’s appointment at DANDRITE and thus, Mark has obtained the full extension for 2022.

2018.11.28 | MarkDenham

Susanne Hvolbøl Buchholdt continues in a permanent employment as technician in Denham Group

Susanne Hvolbøl Buchholdt is a technician in the Denham lab, and her main tasks include culturing and maintaining human pluripotent stem cells. She has also been involved in the reprogramming of Parkinson’s disease patient fibroblasts into induced pluripotent stem cells.

2018.11.12 | MarkDenham

Mark Denham receives DKK 100,000 from Parkinsonforeningen (The Parkinson's Foundation)

Mark Denham receives the grant for the project: "Investigating Genetic Susceptibility in Parkinson’s Disease GBA Heterozygous Carriers".

2018.06.28 | MarkDenham

New publication from Mark Denham’s group

The article on “A Modified Monomeric Red Fluorescent Protein Reporter for Assessing CRISPR Activity” was recently published in the journal Frontiers in Cell and Developmental Biology, with Camilla H. Knudsen, PhD student in the group, as first author.

2018.06.21 | People

Emma Johannsen is new shared Student Assistant in Yonehara, Denham and Nabavi Group

Emma is a new student assistant shared between Mark Denham, Keisuke Yonehara and Sadegh Nabavi. She will mainly be handling autoclavation in connection to class2 labs. Emma is studying Molecular Medicine on her 4th semester. 

2018.02.12 | People

Reyila Simayi is new Erasmus student in Denham Group

Reyila has joined the Denham lab as an Erasmus exchange student for the next 6 months. Her project will involve using human induced pluripotent stem cells to investigating the link between patients with heterozygous GBA mutations and Parkinson’s disease.

2018.02.06 | MarkDenham

New publication from Mark Denham's group in collaboration with Poul Nissen

The article is just published in Frontiers. Title: Central and Peripheral Nervous System Progenitors Derived from Human Pluripotent Stem Cells Reveal a Unique Temporal and Cell-Type Specific Expression of PMCAs.

Picture, Mark Denham

2018.02.02 | MarkDenham

Mark Denham’s Group Leader extension approved

Congratulations to Mark Denham, who has had his group leader contract extended until December 2019.

2017.11.10 | MarkDenham

Mark Denham receives DKK 120,000 from Bjarne Saxhofs Foundation facilitated by the Parkinsons Association

Mark Denham recieves DKK 120,000 for the project: : "A novel Stem Cell model for Parkinson’s disease: Investigating genetic and environmental interactions"

2017.09.26 | People

Fadumo Mohamed is new master student in Denham Group

Fadumo Mohamed is new master student in Mark Denham's group from September 11th. She is a danish student from Aalborg university but she will work full time here until the end of May on the project with title: "Investigating the function of circular RNA during differentiation from stem cells to dopaminergic neurons".…

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