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Karin Lykke-Hartmann

Research Focus

My lab pioneered the generation of a mouse model for ATP1A3-related disorders, harboring the D801Y mutation in the ATP1A3 gene. The α3+/D801Y mice phenocopy many symptoms associated with Alternating Hemiplegia of Childhood (AHC). We concluded that the D801Y is a loss-of-function mutation for Na+/K+ exchange, but are effectively gain-of-function in that the mutant pumps engage full time in proton import, which possibly accounts for the scarcity and severity of these de novo gene alterations and the apparent lack of nonsense mutations (resulting in haploinsufficiency) in the ATP1A3 patient group.

We further generated a mouse model for Familial Hemiplegic Migraine type 2, harboring a disease-mutation in the ATP1A2 gene, which provided a link between the female sex hormone cycle and the glutamate system and a link to co-morbid psychiatric manifestations of FHM2.

News

2019.10.07 | Events

Great symposium on Iceland last week

The 8th Annual Symposium on ATP1A3 in Disease 2019 took place 3-4 October 2019 on Iceland, hosted by the AHC Association of Iceland, and supported by an organizing committee consisting of European scientists working on ATP1A3 related diseases for many years, including three researchers affiliated DANDRITE; Karin Lykke-Hartmann, Hanne Poulsen, and…

2018.05.08 | Awards

Toke Jost Isaksen receives Aarhus University Research Foundation PhD Award

Toke Jost Isaksen, former PhD student in Affiliated Researcher Karin Lykke-Hartmann’s group, is one of the winners of the 2018 Aarhus University Research Foundation PhD Award. Using mice tests Toke Isaksen has localised a defect in the sodium-potassium pump found in brain cells. The discovery may affect future treatment of neurological disorders.…