Schematic illustration of the MhsT transporter, which consists of many thousands of atoms shown here in a surface representation. Red and blue areas are negatively and positively charged, respectively, and grey areas are neutral. The black lines indicate where the protein is located in the cell membrane, and IN and OUT indicate the inside and outside of the cell. The enlarged panel shows the MhsT surface in a semi-transparent version, so you are viewing a centrally located Na+ ion that, in a crystallised state, achieves entry to the inside of the cell through a narrow tunnel, which opens when the transporter slams completely into the outside. The Na+ ion can now escape and, because the intracellular environment has a very low content of Na+, this drives the transporter to transport into the cell – in this case with amino acids and, for the closely related neurotransmitter transporter, with neurotransmitters from the synaptic cleft. (Figure produced by Lina Malinauskaite)

2014.10.28 | Research news

New knowledge about neurotransmitter pathways in the brain

Insight into transport mechanisms in brain cells is extremely important in connection with disorders such as schizophrenia, epilepsy and depression, as well as in connection with producing the right medicine. Defects in proteins responsible for the transport of neurotransmitters are actually related to psychological and neurological disorders, and…

2014.10.28 | People

New postdoc at DANDRITE

Ingrid Dach started as postdoctoral fellow in Poul Nissen's group in June 2014. Ingrid Dach studies structural and functional details of the transport cycle of the sodium-potassium ATPase. Since the malfunction of this membrane pump is linked to a number of of severe neurological diseases such as familial hemiplegic migraine and rapid-onset…

2014.10.27 | Events

DANDRITE Scientific Advisory Board meeting - 6 November 2014

DANDRITE will have the first Scientific Advisory Board Meeting on 6 November 2014. The SAB members, DANDRITE staff, and students will have a full day program. The program includes presentations by all DANDRITE Group Leaders, and in the afternoon there are closed sessions, where the SAB meets all students, postdocs and other staffs.

2014.10.27 | People

New master student at DANDRITE

Anne Kathrine Isager started her master studies in Group Leader Poul Henning Jensen's group on 20 October 2014. Anne Kathrine Isager will be working with the secretion of mutated alpha-synuclein in cell culture and primary culture in relation to Parkinson’s Disease. This could help clarify the secretion and thereby spread of alpha-synuclein and…

2014.10.27 | Research news

New publication from Poul Nissen's group - A mechanism for intracellular release of Na+ by neurotransmitter/sodium symporters

Here, we present two crystal structures of ​MhsT, a Neurotransmitter/sodium symporter member from Bacillus halodurans, in occluded inward-facing states with bound Na+ ions and ​L-tryptophan, providing insight into the cytoplasmic release of Na+.

2014.10.27 | Knowledge exchange

FENS announces grants to young scientists from all around the world to work in labs from Nordic countries

The 10th FENS meeting that will be held in Copenhagen from July 2-6th 2016 (see and An important mission for the Federation of European Neuroscience Societies is to support and facilitate the training of young investigators.

2014.10.27 | Events

DANDRITE & NeuroCampus Seminar - 5 November 2014

Seminar on "Identifying the dynamics of Lewy body formation in Lewy body diseases" by Glenda Halliday from Neuroscience Research Australia and School of Medical Science, Faculty of Medicine, University of New South Wales, Sydney, Australia. The seminar takes places Wednesday 5 November 2014 at 15:00-16:00 in Palle Juul-Jensen/DNC Auditorium, bldg.…

2014.10.21 | People

New PhD student at DANDRITE

Jakob Jensen Ulstrup has started his PhD studies in Poul Nissen’s group on 15 October, 2014. Jakob Ulstrup will be focusing on the lipid flippases (the P4 subfamily of P-type ATPases), which play an important role in establishing the asymmetric distribution of lipids in the cell membrane. His project will focus on the structure determination of…

2014.10.15 | People

New master student at DANDRITE

Marianne Jensen Lundsgaard started her master studies in Group Leader Anders Nykjær's group, under the supervision of Olav Andersen, on 1 October 2014. Marianne Jensen Lundsgaard will be working with APP processing in the retina of a SORLA-deficient mouse model for Alzheimer's Disease. The goal is to determine in which area(s) of the eye sorLA is…

2014.10.13 | News from the management

Job opportunity at DANDRITE - Laborant til forskning i synsnervesystemet

Ansøgningsdeadline 27. Oktober 2014. DANDRITE annoncerer nu en ledig fuldtidsstilling som laborant ved DANDRITE på Aarhus Universitet med ansættelsesstart 1. januar 2015 eller snarest derefter. Stillingen er i første omgang tidsbegrænset til 5 år. Læs hele jobopslaget her (only in Danish).

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